Evidence map›Paper›PMID 30694932›Full record

SynthesisThe Journal of urology2019

Tamsulosin as a Medical Expulsive Therapy for Ureteral Stones: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Yu Cui, Jinbo Chen, Feng Zeng, Peihua Liu, Jiao Hu, Huihuang Li, Chao Li, Xu Cheng, Minfeng Chen, Yangle Li and 6 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Efficacy and Safety of Boldine Combined withMedicina (Kaunas, Lithuania) · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Canadian Urological Association guideline: Management of ureteral calculi - Abridged version.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021
    Article
  14. Canadian Urological Association guideline: Management of ureteral calculi - Full-text.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Yu Cui *Department of Urology, Xiangya Hospital, Central South University , Changsha , China.
Jinbo Chen *Department of Urology, Xiangya Hospital, Central South University , Changsha , China.
Feng ZengDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Peihua LiuDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Jiao HuDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Huihuang LiDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Chao LiDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Xu ChengDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Minfeng ChenDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Yangle LiDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Yang LiDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Zhongqing YangDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Zhiyong ChenDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Harripersaud ChandDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Hequn ChenDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Xiongbing ZuDepartment of Urology, Xiangya Hospital, Central South University , Changsha , China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTamsulosin is widely administered as a medical expulsive therapy to facilitate stone passage in patients with ureteral calculi. Recently several large, multicenter, randomized controlled trials revealed conflicting results, which led to considerable uncertainty about the efficacy of tamsulosin in the management of ureteral stones. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of tamsulosin in the management of ureteral stones. MATERIALS AND

methodsWe searched MEDLINE®, Embase®, Web of Knowledge, Google Scholar™ and the Cochrane Central Search Library databases up to June 2018. Two reviewers independently evaluated eligible randomized controlled trials of the efficacy of tamsulosin to treat ureteral stones. Study quality was assessed with the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system. Subgroup analyses were performed to explore heterogeneity.

resultsIncluded in study were 56 randomized controlled trials in a total of 9,395 patients. The observed treatment effect indicated that tamsulosin was associated with a higher stone expulsion rate (RR 1.44, 95% CI 1.35-1.55, p <0.01), a shorter stone expulsion time (weighted mean difference -0.73, 95% CI -1.00--0.45, p <0.01), a lesser incidence of ureteral colic (weighted mean difference -0.81, 95% CI -1.24--0.39, p <0.01) and fewer incidences of requiring subsequent intervention (RR 0.68, 95% CI 0.50-0.93, p = 0.017). Treatment with tamsulosin did not differ from a control group in the overall incidence of side effects (RR 1.14, 95% CI 0.86-1.51, p = 0.36). On subgroup analysis we observed a significant benefit in the stone expulsion rate for tamsulosin among patients with stones greater than 5 mm (RR 1.44, 95% CI 1.22-1.68, p <0.01) but no effect for stones 5 mm or less (RR 1.08, 95% CI 0.99-1.68, p <0.01).

conclusionsOur current meta-analysis results indicate that tamsulosin is effective and relatively safe in patients with ureteral stone as a medical expulsive therapy to facilitate stone passage. It is suggested to administer it selectively in patients with 5 to 10 mm ureteral stones.

Indexed as

Adrenergic alpha-1 Receptor AntagonistsTamsulosinUreteral CalculiConfidence IntervalsFemaleHumansMaleRandomized Controlled Trials as TopicReference ValuesTreatment OutcomeAdrenergic alpha-1 Receptor AntagonistsTamsulosinChinadrug therapytamsulosinureteral calculiurolithiasis

Identifiers

PMID30694932
OpenAlexW2913895816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.