ArticleEndocrine connections2019
Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases.
Article in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Association of Interleukin-27 (IL-27) rs181206 T/C and rs17855750 T/G Gene Polymorphisms and the Risk of Hepatitis B Infection among Egyptians.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The function of long non-coding RNA IFNG-AS1 in autoimmune diseases.Human cell · 2024Review
- STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan.Gene reports · 2024Article
- Association between interleukin-27 gene polymorphisms andInnate immunity · 2023Article
- Article
- Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population.African health sciences · 2022Article
- Association Between HOTAIR rs920778 and H19 rs3741219 Polymorphisms with Hashimoto's Thyroiditis (HT) and Graves' Disease (GD).Reports of biochemistry & molecular biology · 2022Article
- Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level.Journal of clinical medicine · 2021Article
- Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease.Biomolecules · 2021Article
- IL-30Experimental & molecular medicine · 2021Review
- The paths of Graves' disease in the 21st century: precision medicine is closer.Archives of endocrinology and metabolism · 2020Article
- Long non-coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population.Thoracic cancer · 2020Article
- Increased Human Interleukin-32 Expression Is Related to Disease Activity of Graves' Disease.Frontiers in endocrinology · 2019Article
- IL27 T4730C Polymorphism and Serology in Multiple Sclerosis: A Pilot Study.In vivo (Athens, Greece)Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Methods Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 Graves' disease (GD) and 327 Hashimoto's thyroiditis (HT)) and 677 healthy controls in Chinese Han population. Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206. Conclusion Our study, for the first time, showed the significant association of the IL27 gene SNPs with AITD.
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