Evidence map›Paper›PMID 30694690›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.

Matthew T Dickerson, Prasanna K Dadi, Molly K Altman, Kenneth R Verlage, Ariel S Thorson, Kelli L Jordan, Nicholas C Vierra, Gautami Amarnath, David A Jacobson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Metabolic Messengers: glucagon.Nature metabolism · 2023
    Review
  3. Liraglutide increases islet CaDiabetes, obesity & metabolism · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Lactate activation of α-cell KMolecular metabolism · 2020
    Article
  10. Mechanisms of the Regulation and Dysregulation of Glucagon Secretion.Oxidative medicine and cellular longevity · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.ORCID 0000-0002-6187-3951
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Molly K AltmanDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Kenneth R VerlageDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Ariel S ThorsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Kelli L JordanDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.ORCID 0000-0002-4219-0143
Nicholas C VierraDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Gautami AmarnathDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Vanderbilt University · USTexas Tech University · US

Funding

Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Two-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3M
Designing selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetesR01DK115620 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2018 to 2021
$1.6M
NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK115620NIDDK NIH HHS T32 DK007563NIDDK NIH HHS T32 DK101003NIDDK NIH HHS U24 DK098085
6 · The paper itself

Abstract

Pancreatic α-cells exhibit oscillations in cytosolic Ca

Indexed as

AlkanesAnimalsApaminCalciumCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, P-TypeCalcium Channels, Q-TypeEndoplasmic ReticulumGlucagonGlucagon-Secreting CellsGlucoseMiceMice, TransgenicPatch-Clamp TechniquesPeptides6,10-diaza-3(1,3),8(1,4)dibenzena-1,5(1,4)diquinolinacyclodecaphaneAlkanesApaminCalciumCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, P-TypeCalcium Channels, Q-TypeGlucagonGlucoseiberiotoxinPeptidesPotassium Channel BlockersPotassium Channels, Calcium-ActivatedPyrazolesQuinolinium CompoundsTRAM 34calcium handlingglucagon secretionpotassium channelα-cell

Identifiers

PMID30694690
PMCPMC6482666
OpenAlexW2912873485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.