SynthesisPediatric pulmonology2019
Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis.
Synthesis in Pediatric pulmonology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis.Pediatric pulmonology · 2019Pooled it
- Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia.Scientific reports · 2023Trial
- Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
- Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia.Pediatric pulmonology · 2024Article
- Prematurity-associated lung disease: is it asthma?ERJ open research · 2024Article
- Long-term pulmonary outcomes of young adults born prematurely: a Polish prospective cohort study PREMATURITAS 20.BMC pulmonary medicine · 2024Article
- Evolving treatment for prematurity-associated lung disease.Translational pediatrics · 2024Article
- Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm.Pediatric pulmonology · 2023Article
- Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease.Thorax · 2023Article
- Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease.Pediatric pulmonology · 2022Article
- Association of early-life factors with prematurity-associated lung disease: prospective cohort study.The European respiratory journal · 2022Article
- Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life.Pediatric pulmonology · 2021Article
- Understanding hydrogen sulfide signaling in neonatal airway disease.Expert review of respiratory medicine · 2021Review
- Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age.Frontiers in pediatrics · 2021Article
- Voice and Exercise Related Respiratory Symptoms in Extremely Preterm Born Children After Neonatal Patent Ductus Arteriosus.Frontiers in pediatrics · 2020Article
- Bronchopulmonary dysplasia: what are its links to COPD?Therapeutic advances in respiratory diseaseReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDecreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term-born controls.
methodsWe searched eight databases up to February 2018. Studies comparing FeNO levels in preterm-born subjects (<37 weeks' gestation) in childhood and adulthood with and without (CLD) with term-born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3.
resultsFrom 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in preterm- and term-born children and adults; 11 studies (preterm n = 640 and term n = 4005) were included in a meta-analysis. The mean FeNO concentration difference between the preterm-born and term-born group was -0.74 (95% CI -1.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm n = 204 and term n = 211) the mean difference for FeNO levels was -2.82 (95% CI -5.87 to 0.22) ppb between the preterm-born CLD and term-born groups.
conclusionsOur data suggest that preterm born children with and without CLD have similar FeNO levels to term-born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm-born subjects.
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Registered trials
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