Evidence map›Paper›PMID 30694393›Full record

ArticleMedical oncology (Northwood, London, England)2019

Deficiency of mismatch repair genes is less frequently observed in signet ring cell compared with non-signet ring cell gastric cancer.

Yosuke Hirotsu, Hitoshi Mochizuki, Kenji Amemiya, Hiroshi Ohyama, Dai Yoshimura, Hiroyuki Amano, Yuko Miura, Hiroshi Ashizawa, Keiko Nakagomi, Shinya Takaoka and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  10. Signaling pathways and therapeutic interventions in gastric cancer.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Yosuke HirotsuGenome Analysis Center, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu, Yamanashi, Japan. hirotsu-bdyu@ych.pref.yamanashi.jp.ORCID http://orcid.org/0000-0002-8002-834X
Hitoshi MochizukiGenome Analysis Center, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu, Yamanashi, Japan.
Kenji AmemiyaGenome Analysis Center, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu, Yamanashi, Japan.
Hiroshi OhyamaGenome Analysis Center, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu, Yamanashi, Japan.
Dai YoshimuraDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Hiroyuki AmanoDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Yuko MiuraDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Hiroshi AshizawaDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Keiko NakagomiDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Shinya TakaokaDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Kenji HosodaDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Yoji SuzukiDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Toshio OyamaDepartment of Pathology, Yamanashi Central Hospital, Kofu, Japan.
Masao HadaDepartment of Surgery, Yamanashi Central Hospital, Kofu, Japan.
Yuichiro KojimaDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Japan.
Masao OmataGenome Analysis Center, Yamanashi Central Hospital, 1-1-1, Fujimi, Kofu, Yamanashi, Japan.
Yamanashi Prefectural Central Hospital · JPChiba University · JP

Funding

Japan Society for the Promotion of Science JP18K16292
6 · The paper itself

Abstract

Signet ring cell (SRC) gastric cancer at advanced stage has poor prognosis. While a recent study reported nearly one-third of SRC cases contain tumors with deficient mismatch repair (MMR) genes, other studies in SRC have been inconclusive. To re-analyze the results, we performed immunohistochemical staining of MLH1, MSH2, MSH6 and PMS2 proteins in 38 SRC gastric tumors compared with 109 non-SRC (NSRC) tumors from 94 patients. In contrast to the previous study, all SRC gastric tumors normally expressed MMR proteins, whereas 22 of 109 of NSRC (20%) showed deficient MMR proteins. To reinforce our results, we referred to the Cancer Genome Atlas (TCGA) genomic database and found that only 6 (6%) of 99 samples with diffuse gastric tumors showed deficient MMR, whereas 64 (21%) of 304 in intestinal gastric tumors showed deficient MMR. Our results as well as the TCGA database indicated that MMR genes are infrequently inactivated in SRC gastric cancer. These findings indicate that SRC patients may not be the best candidates for immuno-oncology therapy.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Signet Ring CellDNA Mismatch RepairFemaleHumansMaleMicrosatellite InstabilityMiddle AgedStomach NeoplasmsGastric cancerImmune checkpoint inhibitorMicrosatellite instabilityNon-signet ring cellSignet ring cell

Identifiers

PMID30694393
OpenAlexW2913572326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.