Evidence map›Paper›PMID 30694174›Full record

ArticleeLife2019

Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling.

Evanthia Zacharioudaki, Julia Falo Sanjuan, Sarah Bray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Drosophila as a Model for Metastasis.Advances in experimental medicine and biology · 2025
    Review
  3. Notch Signaling in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  4. The functionalFrontiers in immunology · 2025
    Article
  5. Article
  6. Article
  7. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Evanthia ZacharioudakiDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Knigdom.
Julia Falo SanjuanDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Knigdom.ORCID 0000-0002-3563-4789
Sarah BrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Knigdom.ORCID 0000-0002-1642-599X

Funding

Medical Research Council MR/L007177/1Wellcome TrustWellcome Trust 109144/Z/15/Z
6 · The paper itself

Abstract

To progress towards differentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In

Indexed as

Adenosine TriphosphatasesAnimalsAutoantigensBasic Helix-Loop-Helix ProteinsCarcinogenesisCell DifferentiationCell LineageCell ProliferationDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalHumansHyperplasiaModels, BiologicalNeural Stem CellsNeuronsAdenosine TriphosphatasesAutoantigensBasic Helix-Loop-Helix ProteinsDrosophila ProteinsE(spl)m7-HLH protein, DrosophilaMi-2 protein, DrosophilaN protein, DrosophilaReceptors, NotchRepressor Proteinschromosomesdevelopmental biologyD. melanogastergene expressionNotchNuRD Complexstem cells

Identifiers

PMID30694174
PMCPMC6379090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.