ArticleRespirology (Carlton, Vic.)2019
BMI but not central obesity predisposes to airway closure during bronchoconstriction.
Article in Respirology (Carlton, Vic.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026Review
- Small airway dysfunction links asthma exacerbations with asthma control and health-related quality of life.Respiratory research · 2024Observational
- Obesity-associated Airway Hyperresponsiveness: Mechanisms Underlying Inflammatory Markers and Possible Pharmacological Interventions.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Bronchodilator reversibility testing in morbidly obese non-smokers: fluticasone/salmeterol efficacy versus salbutamol bronchodilator.BMC pulmonary medicine · 2023Article
- Reference equations for oscillometry and their differences among populations: a systematic scoping review.European respiratory review : an official journal of the European Respiratory Society · 2022Article
- Association between age, gender, body mass index, and pulmonary function in preoperative patients with lung cancer.The clinical respiratory journal · 2022Observational
- The Relationship Between BMI and Lung Function in Populations with Different Characteristics: A Cross-Sectional Study Based on the Enjoying Breathing Program in China.International journal of chronic obstructive pulmonary disease · 2022Article
- Obesity, Inflammation, and Severe Asthma: an Update.Current allergy and asthma reports · 2021Review
- Association between air flow limitation and body composition in young adults.Journal of physiological anthropology · 2021Article
- The Effects of Asthma on the Association Between Pulmonary Function and Obesity: A 16-Year Longitudinal Study.Journal of asthma and allergy · 2021Article
- Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction.ERJ open research · 2021Article
- Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?Physiological reviews · 2020Review
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveObesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. This study investigates the effect of body mass index (BMI) versus waist circumference (WC) on spirometric lung function, sensitivity to airway narrowing and closure, and airway closure during bronchoconstriction in patients with asthma.
methodsParticipants underwent spirometry and methacholine challenge. Sensitivity to airway closure and narrowing was assessed from the dose-response slopes of the forced vital capacity (FVC) and the ratio of forced expiratory volume in 1 s (FEV
resultsA total of 116 asthmatic patients (56 obese) underwent methacholine challenge. Spirometric lung function was inversely related to WC (P < 0.05), rather than BMI. Closing index increased significantly during bronchoconstriction in obese patients and was related to increasing BMI (P = 0.01), but not to WC. Sensitivity to airway closure and narrowing was not associated with BMI or WC.
conclusionAlthough WC is associated with restrictive effects on baseline lung function, increased BMI, rather than WC, predisposes to airway closure during bronchoconstriction. These findings suggest that obesity predisposes to airway closure during bronchoconstriction through mechanisms other than simple mass loading.
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