ArticleeLife2019
Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
- Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.The Journal of clinical investigation · 2025Trial
- Polyketide synthase 12 is anbioRxiv : the preprint server for biology · 2026Article
- Effects on mouse melanoma and immune cells of P2X7 receptor positive allosterism by clemastine.Purinergic signalling · 2026Article
- MALAT1-miR-20b-5p-P2RX7 Axis RegulatesVeterinary sciences · 2026Article
- Calcium Signaling in Macrophages During a Wound Response In Vivo.International journal of molecular sciences · 2026Article
- Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.Science advances · 2026Article
- The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish.Disease models & mechanisms · 2025Article
- Channeling kynurenine.Nature chemical biology · 2024Article
- 3-Hydroxykynurenine targets kainate receptors to promote defense against infection.Nature chemical biology · 2024Article
- Prophylactic clemastine treatment improves influenza A virus-induced cognitive dysfunction in mice.Brain, behavior, & immunity - health · 2024Article
- Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy.Disease models & mechanisms · 2024Article
- Diving into drug-screening: zebrafish embryos as an in vivo platform for antimicrobial drug discovery and assessment.FEMS microbiology reviews · 2024Review
- The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model.The Journal of antibiotics · 2024Article
- Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages.Purinergic signalling · 2024Article
- Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer's disease seed-dependent formation of tau aggregates.Frontiers in aging neuroscience · 2024Article
- Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis.Scientific reports · 2023Article
- Animal Models for the Investigation of P2X7 Receptors.International journal of molecular sciences · 2023Review
- Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish.Biology · 2023Review
- Article
- Resistance and Susceptibility Immune Factors at Play duringPathogens (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Molly A MattyDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.ORCID 0000-0002-4542-2800
Daphne R KnudsenDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.
Eric M WaltonDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.
Rebecca W BeermanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.
Mark R CronanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.
Charlie J PyleDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.
Rafael E HernandezCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, United States.ORCID 0000-0003-4408-7411
David M TobinDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, United States.ORCID 0000-0003-3465-5518
Duke University · USInfectious Disease Research Institute · US
Funding
ACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7MMacrophage Reprogramming During Granuloma Formation in the ZebrafishR01AI130236 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.5MGenetic dissection of angiogenesis in the tuberculous granulomaR01AI125517 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.4MThe Genetic Basis of Bone Disease in Mycobacterial InfectionR01AI127715 · NIAID · DUKE UNIVERSITY · PI Clare Margaret Smith, David M. Tobin · 2017 to 2026
$3.3MThe role of mycobacterial efflux pumps in virulence and antibiotic toleranceK08AI116908 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI HERNANDEZ, RAFAEL E · 2015 to 2019
$873kLightsheet Imaging SystemS10OD020010 · OD · DUKE UNIVERSITY · PI CAMERON, LISA A. · 2016 to 2016
$597kAmerican Cancer Society Postdoctoral FellowshipNational Science Foundation GRFPNIAID NIH HHS K08 AI116908NIAID NIH HHS R01 AI125517NIAID NIH HHS R01 AI127715NIAID NIH HHS R01 AI130236NICHD NIH HHS T32 HD007233NIH HHS 1S10OD020010NIH HHS AI116908NIH HHS AI125517NIH HHS AI127115NIH HHS AI130236NIH HHS HD007233NIH HHS S10 OD020010Vallee Foundation Vallee Scholar Award
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAnti-Allergic AgentsAntitubercular AgentsCalciumClemastineDisease Models, AnimalDrug RepositioningGene Expression RegulationGranulomaHost-Pathogen InteractionsHumansImmunity, InnateInflammasomesLarvaMacrophagesMycobacterium Infections, NontuberculousAnti-Allergic AgentsAntitubercular AgentsCalciumClemastineInflammasomesReceptors, Purinergic P2X7Zebrafish Proteinshost-directed therapiesimmunologyinfectious diseaseinflammationlight sheet microscopymicrobiologymycobacteriump2rx7phenotypic drug screeningzebrafish
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.