Evidence map›Paper›PMID 30693575›Full record

ArticleMolecular microbiology2019

Agrobacterium tumefaciens divisome proteins regulate the transition from polar growth to cell division.

Matthew Howell, Alena Aliashkevich, Kousik Sundararajan, Jeremy J Daniel, Patrick J Lariviere, Erin D Goley, Felipe Cava, Pamela J B Brown

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. The polar landscape of bacterial pathogens and predators.Current opinion in microbiology · 2026
    Review
  2. Article
  3. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. Article
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  15. Article
  16. Article
  17. Article
  18. Regulation of peptidoglycan synthesis and remodelling.Nature reviews. Microbiology · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Matthew HowellDivision of Biological Sciences, University of Missouri, Columbia, MO, 65203, USA.
Alena AliashkevichDepartment of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Kousik SundararajanDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jeremy J DanielDivision of Biological Sciences, University of Missouri, Columbia, MO, 65203, USA.
Patrick J LariviereDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Erin D GoleyDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-8518-2303
Felipe CavaDepartment of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Pamela J B BrownDivision of Biological Sciences, University of Missouri, Columbia, MO, 65203, USA.ORCID 0000-0002-7558-7155
Johns Hopkins University · USUniversity of Missouri · USUmeå University · SE

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Regulation and Mechanism of the C. Crescentus Cytokinetic RingR01GM108640 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GOLEY, ERIN D · 2015 to 2019
$1.6M
NIGMS NIH HHS R01 GM108640NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

The mechanisms that restrict peptidoglycan biosynthesis to the pole during elongation and re-direct peptidoglycan biosynthesis to mid-cell during cell division in polar-growing Alphaproteobacteria are largely unknown. Here, we explore the role of early division proteins of Agrobacterium tumefaciens including three FtsZ homologs, FtsA and FtsW in the transition from polar growth to mid-cell growth and ultimately cell division. Although two of the three FtsZ homologs localize to mid-cell, exhibit GTPase activity and form co-polymers, only one, FtsZ

Indexed as

Cell DivisionGene Expression Regulation, BacterialAgrobacterium tumefaciensBacterial ProteinsCell CycleCell Cycle ProteinsCytoskeletal ProteinsPeptidoglycanBacterial ProteinsCell Cycle ProteinsCytoskeletal ProteinsFtsZ protein, BacteriaPeptidoglycan

Identifiers

PMID30693575
PMCPMC6482847
OpenAlexW2951848529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.