ArticlePsychophysiology2019
Loneliness and biological responses to acute stress in people with Type 2 diabetes.
Article in Psychophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Feasibility and Preliminary Impacts of a Diabetes Education Chatbot Simulation on Glycemic Targets, Loneliness, and Health Beliefs in Indonesia: An Explanatory Mixed-methods Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Loneliness, social isolation and stroke risk in men and women with and without diabetes.BMC public health · 2025Article
- Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study.Cellular and molecular neurobiology · 2025Article
- Psychosocial and behavioral risk patterns and risk of cardiovascular complications in people with type 2 diabetes.Diabetes research and clinical practice · 2025Article
- Investigating the prevalence and associated factors of depression, anxiety, and loneliness among people with type-2 diabetes in Bangladesh: a community-based study.Scientific reports · 2024Article
- Loneliness in older adults with diabetes mellitus: a scoping review.Psychology, health & medicine · 2024Article
- The Association of Loneliness with Diabetes Is Mediated by Physical Activity and BMI but Not Diet Quality.Nutrients · 2023Article
- Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization.EClinicalMedicine · 2023Article
- Dysregulated responses to stress and weight in people with type 2 diabetes.Journal of psychosomatic research · 2023Article
- Correlation analysis of monocyte chemoattractant protein-1 and clinical characteristics and cognitive impairment in type 2 diabetes mellitus comorbid major depressive disorder.Frontiers in aging neuroscience · 2023Article
- Loneliness increases the risk of type 2 diabetes: a 20 year follow-up - results from the HUNT study.Diabetologia · 2023Article
- Loneliness: An Immunometabolic Syndrome.International journal of environmental research and public health · 2021Review
- Systematic review of psychometric properties and cross-cultural adaptation of the University of California and Los Angeles loneliness scale in adults.Current psychology (New Brunswick, N.J.) · 2021Article
- Factors associated with loneliness in patients with diabetes mellitus.Nursing open · 2021Article
- Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing.Diabetologia · 2020Article
- Relationship between loneliness and blood glucose control in diabetes.BMC public health · 2020Article
- The relationship between sleep problems and cortisol in people with type 2 diabetes.Psychoneuroendocrinology · 2020Article
- Loneliness and biological responses to acute stress in people with Type 2 diabetes.Psychophysiology · 2019Article
- Loneliness and Other Factors Associated with Physical Activity in Older Adults with Diabetes: A Cross-Sectional Study.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Loneliness is linked with all-cause mortality and coronary heart disease. Altered neuroendocrine and inflammatory responses to stress constitute potential pathways linking loneliness and ill-health. Stress responsivity is modified in people with Type 2 diabetes, but it is unclear whether loneliness influences biological stress responses in this population. We assessed interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1RA), monocyte chemoattractant protein-1 (MCP-1), and cortisol responses to acute stress in 135 people with Type 2 diabetes. Loneliness was measured used the Revised UCLA Loneliness Scale. Loneliness was inversely associated with cortisol output poststress (B = -4.429, p = 0.019) independent of age, sex, education, marital status, body mass index, and smoking. Lonelier individuals had raised MCP-1 concentrations 75 min poststress independent of covariates (B = 0.713, p = 0.022). No associations between loneliness and IL-6 or IL-1RA concentrations were detected. These results suggest that loneliness is associated with disturbances in stress responsivity in people with diabetes, and the impact of loneliness on health in people with diabetes may be mediated in part through dysregulation of inflammatory and neuroendocrine systems. Future research is required to understand if such changes increase the risk of poorer outcomes in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.