Evidence map›Paper›PMID 30693425›Full record

ArticleTranslational stroke research2019

Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury.

Jyoti Gautam, Jeffrey H Miner, Yao Yao

Open access · greenAbstract read
In one paragraph

Article in Translational stroke research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Laminins and the blood-brain barrier.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  12. Review
  13. A dispensable role of mural cell-derived laminin-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  14. Review
  15. Article
  16. A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  17. Article
  18. Article
  19. The importance of laminin at the blood-brain barrier.Neural regeneration research · 2023
    Review
  20. Causes of Hemorrhagic Stroke: a Cellular Perspective.Translational stroke research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jyoti GautamDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, 30602, USA.
Jeffrey H MinerDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Yao YaoDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, 30602, USA. yyao@uga.edu.ORCID 0000-0001-8020-9696
University of Georgia · USWashington University in St. Louis · US

Funding

LAMININS AND GLOMERULAR FILTRATIONR01DK078314 · NIDDK · WASHINGTON UNIVERSITY · PI MINER, JEFFREY H · 2008 to 2021
$5.4M
American Heart Association-American Stroke Association 16SDG29320001NIDDK NIH HHS R01 DK078314
6 · The paper itself

Abstract

Endothelial cells make laminin-411 and laminin-511. Although laminin-411 is well studied, the role of laminin-511 remains largely unknown due to the embryonic lethality of lama5

Indexed as

AnimalsAstrocytesBlood-Brain BarrierBrain EdemaBrain InjuriesCerebral HemorrhageCollagenasesDisease Models, AnimalEndothelial CellsFemaleLamininMaleMiceMice, KnockoutPericytesTight Junction ProteinsCollagenasesLamininlaminin-511, mouselaminin alpha5Tight Junction ProteinsBlood-brain barrierEndothelial cellsIntracerebral hemorrhageLaminin

Identifiers

PMID30693425
PMCPMC6663661
OpenAlexW2911711521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.