Evidence map›Paper›PMID 30693401›Full record

ArticleClinical oral investigations2019

Influence of buffy coat-derived putative endothelial progenitor cells on tumor growth and neovascularization in oral squamous cell carcinoma xenografts.

Marius Otto, Sebastian Blatt, Andreas Pabst, Robert Mandic, Johanna Schwarz, Andreas Neff, Thomas Ziebart

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marius OttoInterdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany.ORCID http://orcid.org/0000-0002-1622-4944
Sebastian BlattClinic for Oral and Maxillofacial Surgery, University Medical Center Mainz, Mainz, Germany.
Andreas PabstClinic for Oral and Maxillofacial Surgery, Federal Armed Forces Hospital Koblenz, Koblenz, Germany.
Robert MandicInterdisciplinary Head & Neck Oncology Laboratory, Department of Otolaryngology, Head & Neck Surgery, University Hospital Marburg, Marburg, Germany.
Johanna SchwarzDepartment of Mathematics and Computer Science, Research Group for Bioinformatics, Philipps-Universität Marburg, Marburg, Germany.
Andreas NeffInterdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany.
Thomas ZiebartInterdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany. ziebart@med.uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this murine in vivo study was to investigate whether buffy coat-derived putative endothelial progenitor cells (BC MATERIALS AND

methodsA murine xenograft model using the PCI-13 oral cancer cell line was deployed of which n = 24 animals received 2 × 10

resultsIn the experimental group, systemic application of BC

conclusionsImmunohistochemical investigations support the notion that BC CLINICAL RELEVANCE: Endothelial progenitor cells (EPCs) could serve as a target structure for the treatment of OSCC and possibly other solid tumors.

Indexed as

Neovascularization, PathologicAnimalsBlood Buffy CoatCarcinoma, Squamous CellEndothelial Progenitor CellsFemaleHeterograftsHumansMiceMice, Inbred NODMice, NudeMice, SCIDMouth NeoplasmsTransplantation, HeterologousEndothelial progenitor cellLymphangiogenesisNeovascularizationOral cancer

Identifiers

PMID30693401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.