ArticleeNeuro
Sexually Dimorphic Vasopressin Cells Modulate Social Investigation and Communication in Sex-Specific Ways.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Connectivity and phenotype of vasopressin 1a receptor cells in the lateral septum.bioRxiv : the preprint server for biology · 2025Article
- Sexually dimorphic distribution of Kiss1 neurons in the bed nucleus of the stria terminalis.Journal of neuroendocrinology · 2025Article
- Sex difference in the effects of ventral pallidum vasopressin 1a receptor partial knockdown on social behavior in mice.Hormones and behavior · 2025Article
- Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3BNature communications · 2025Article
- Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior.Nature communications · 2025Article
- Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques.Biomolecules · 2025Article
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- The deletion of the arginine vasopressin 1a receptor impairs sexual and maternal behavior.Frontiers in endocrinology · 2025Article
- Ventral subiculum control of avoidance behavior and hypothalamic-pituitary-adrenal axis reactivity via the bed nucleus of the stria terminalis in male and female mice - ISPNE 2024 Dirk Helhammer Award.Psychoneuroendocrinology · 2025Article
- Altered vocal communication in adult vasopressin-deficient Brattleboro rats.Physiology & behavior · 2024Article
- The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents.Neuroscience and biobehavioral reviews · 2024Review
- Sex differences in the structure and function of the vasopressin system in the ventral pallidum are associated with the sex-specific regulation of social play behavior in juvenile rats.Hormones and behavior · 2024Article
- A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.The Journal of comparative neurology · 2024Article
- Prenatal allergic inflammation in rats confers sex-specific alterations to oxytocin and vasopressin innervation in social brain regions.Hormones and behavior · 2024Article
- A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in mice.bioRxiv : the preprint server for biology · 2023Article
- Sex differences in afferents and efferents of vasopressin neurons of the bed nucleus of the stria terminalis and medial amygdala in mice.Hormones and behavior · 2023Article
- Uncovering the brain-wide pattern of synaptic input to vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus.The Journal of comparative neurology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The neuropeptide arginine vasopressin (AVP) has long been implicated in the regulation of social behavior and communication, but precisely which AVP cell groups are involved is largely unknown. To address whether the sexually dimorphic AVP cell group in the bed nucleus of the stria terminalis (BNST) is important for social communication, we deleted BNST AVP cells by viral delivery of a Cre-dependent caspase-3 cell-death construct in AVP-iCre-positive mice using AVP-iCre negative littermate as controls, and assessed social, sexual, aggressive and anxiety-related behaviors. In males, lesioning BNST AVP cells reduced social investigation of other males and increased urine marking (UM) in the presence of a live female, without altering ultrasonic vocalizations (USVs), resident-intruder aggression, copulatory behavior, anxiety, or investigation of females or their odor cues. In females, which have significantly fewer AVP cells in the BNST, these injections influenced copulatory behavior but otherwise had minimal effects on social behavior and communication, indicating that these cells contribute to sex differences in social behavioral function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.