ArticleeNeuro
Prefrontal Theta Oscillations Promote Selective Encoding of Behaviorally Relevant Events.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- SMR/Theta Neurofeedback Training on Attention and Reading Abilities in Children with Attention Deficit Hyperactivity Disorder-Predominantly Inattentive.Applied psychophysiology and biofeedback · 2026Article
- Identification of EEG features during status epilepticus for prediction of emergent epilepsy phenotype in the mouse intra-amygdala kainic acid model using supervised learning.IBRO neuroscience reports · 2026Article
- Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning.Experimental neurobiology · 2025Article
- Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Infants evaluate informativeness of evidence and predict causal events as revealed in theta oscillations and predictive looking.Communications psychology · 2024Article
- Functional network of contextual and temporal memory has increased amygdala centrality and connectivity with the retrosplenial cortex, thalamus, and hippocampus.Scientific reports · 2023Article
- Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning.Scientific reports · 2022Article
- Contextual memory reactivation modulates CaScientific reports · 2022Article
- Outcome-Locked Cholinergic Signaling Suppresses Prefrontal Encoding of Stimulus Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Coherent theta activity in the medial and orbital frontal cortices encodes reward value.eLife · 2021Article
- Entorhinal cortical Island cells regulate temporal association learning with long trace period.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Prefrontal Neural Ensembles Develop Selective Code for Stimulus Associations within Minutes of Novel Experiences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex.Journal of neurophysiology · 2020Article
- Increases in theta CSD power and coherence during a calibrated stop-signal task: implications for goal-conflict processing and the Behavioural Inhibition System.Personality neuroscience · 2019Article
- Prefrontal-hippocampal interaction during the encoding of new memories.Brain and neuroscience advancesReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ability to capture the most relevant information from everyday experiences without constantly learning unimportant details is vital to survival and mental health. While decreased activity of the medial prefrontal cortex (mPFC) is associated with failed or inflexible encoding of relevant events in the hippocampus, mechanisms used by the mPFC to discern behavioral relevance of events are not clear. To address this question, we chemogenetically activated excitatory neurons in the mPFC of male rats and examined its impact on local network activity and differential associative learning dependent on the hippocampus. Rats were exposed to two neutral stimuli in two environments whose contingency with an aversive stimulus changed systematically across days. Over 2 weeks of differential and reversal learning, theta band activity began to ramp up toward the expected onset of the aversive stimulus, and this ramping activity tracked the subsequent shift of the set (stimulus modality to environment) predictive of the aversive stimulus. With chemogenetic mPFC activation, the ramping activity emerged within a few sessions of differential learning, which paralleled faster learning and stronger correlations between the ramping activity and conditioned responses. Chemogenetic mPFC activity, however, did not affect the adjustment of ramping activity or behavior during reversal learning or set-shifting, suggesting that the faster learning was not because of a general enhancement of attention, sensory, or motor processing. Thus, the dynamics of the mPFC network activation during events provide a relevance-signaling mechanism through which the mPFC exerts executive control over the encoding of those events in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.