ArticleFrontiers in bioengineering and biotechnology2018
Advantages of Hydrogel-Based 3D-Printed Enzyme Reactors and Their Limitations for Biocatalysis.
Article in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- 3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications.Chemistry, an Asian journal · 2024Review
- Enzyme Engineering: Performance Optimization, Novel Sources, and Applications in the Food Industry.Foods (Basel, Switzerland) · 2024Review
- Alginate and Chitosan-Based Hydrogel Enhance Antibacterial Agent Activity on Topical Application.Infection and drug resistance · 2024Review
- Carbonic Anhydrase Enhanced UV-Crosslinked PEG-DA/PEO Extruded Hydrogel Flexible Filaments and Durable Grids for COGels (Basel, Switzerland) · 2023Article
- Continuous Flow Biocatalytic Reductive Amination by Co-Entrapping Dehydrogenases with Agarose Gel in a 3D-Printed Mould Reactor.Chembiochem : a European journal of chemical biology · 2022Article
- Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering.ACS central science · 2022Article
- Advances in 3D Gel Printing for Enzyme Immobilization.Gels (Basel, Switzerland) · 2022Review
- Emerging 3D Printing Strategies for Enzyme Immobilization: Materials, Methods, and Applications.ACS omega · 2022Review
- Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis.Engineering in life sciences · 2022Review
- Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds.International journal of molecular sciences · 2021Review
- Miniaturization and 3D Printing of Bioreactors: A Technological Mini Review.Micromachines · 2020Review
- 3D-Printable and Enzymatically Active Composite Materials Based on Hydrogel-Filled High Internal Phase Emulsions.Frontiers in bioengineering and biotechnology · 2020Article
- Simulative Minimization of Mass Transfer Limitations Within Hydrogel-Based 3D-Printed Enzyme Carriers.Frontiers in bioengineering and biotechnology · 2020Article
- 3D-Printed Phenacrylate Decarboxylase Flow Reactors for the Chemoenzymatic Synthesis of 4-Hydroxystilbene.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The development of process steps catalyzed by immobilized enzymes usually encompasses the screening of enzyme variants, as well as the optimization of immobilization protocols and process parameters. Direct immobilization of biocatalysts by physical entrapment into hydrogels can be applied to reduce the effort required for immobilization, as the enzyme-specific optimization of the immobilization procedure is omitted. Physical entrapment is applicable for purified enzymes as well as crude cell extracts. Therefore, it can be used to quickly assess and compare activities of immobilized enzymes. For the application in flow reactors, we developed 3D-printed hydrogel lattices for enzyme entrapment as well as matching housings, also manufactured by 3D-printing. Testing the resulting enzyme reactors for three different enzymes, namely alcohol dehydrogenase from
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