Evidence map›Paper›PMID 30693139›Full record

ArticleTurkish journal of obstetrics and gynecology2018

Ykl-40 and cancer antigen 72-4 as new and promising diagnostic and prognostic markers for endometrial cancer.

Suat Karataş, Veysel Şal, İlker Kahramanoğlu, Fuat Demirkıran, Tugan Beşe, Macit Arvas, Nigar Sofiyeva, Onur Güralp, Hafize Uzun

Abstract read
In one paragraph

Article in Turkish journal of obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suat Karataşİstanbul Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.ORCID https://orcid.org/0000-0003-1592-0304
Veysel Şalİstanbul Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey.ORCID https://orcid.org/0000-0002-5698-3734
İlker Kahramanoğluİstanbul University Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, İstanbul, Turkey.ORCID https://orcid.org/0000-0003-0956-1050
Fuat Demirkıranİstanbul University Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, İstanbul, Turkey.ORCID https://orcid.org/0000-0002-0439-2502
Tugan Beşeİstanbul University Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, İstanbul, Turkey.ORCID https://orcid.org/0000-0003-4866-1695
Macit Arvasİstanbul University Cerrahpaşa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, İstanbul, Turkey.ORCID https://orcid.org/0000-0003-2548-1667
Nigar SofiyevaYale University Faculty of Medicine, Department of Obstetrics and Gynecology and Reproductive Sciences, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-9998-4040
Onur GüralpKlinikum Oldenburg University Hospital, Clinic of Obstetrics and Gynecology, Oldenburg, Germany.ORCID https://orcid.org/0000-0002-3626-7423
Hafize Uzunİstanbul University Cerrahpaşa Faculty of Medicine, Department of Biochemistry, İstanbul,Turkey.ORCID https://orcid.org/0000-0002-1347-8498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the predictive role of serum levels of YKL-40 and cancer antigen (CA) 72-4 in the diagnosis of endometrial cancer (EC). MATERIALS AND

methodsForty-one patients with EC and 21 women with uterine polyps were evaluated between January and December 2015 in a prospective study.

resultsAge, body mass index, preoperative serum YKL-40 and CA 72-4 levels were significantly higher in the malignant group compared with the control group. Serum YKL-40 levels were significantly higher in patients with superficial myometrial invasion and no lymph node involvement (p=0.042; p=0.004). No relationship between clinicopathologic factors and serum CA 72-4 levels was found.

conclusionSerum CA 72-4 and YKL-40 levels are increased in women with EC compared with uterine polyps. Preoperative serum YKL-40 levels may be associated with favorable prognostic factors. The determination of YKL-40 before surgery may be helpful in the evaluation of the regional lymph nodes.

Indexed as

cancer antigen 72-4endometrial cancerscreeningYKL-40

Identifiers

PMID30693139
PMCPMC6334238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.