Evidence map›Paper›PMID 30693107›Full record

ArticleJournal of pregnancy2019

The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth.

Rima Irwinda, Noroyono Wibowo, Atikah Sayogo Putri

Open access · goldAbstract read
In one paragraph

Article in Journal of pregnancy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
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  5. Review
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  8. Article
  9. Copper homeostasis and pregnancy complications: a comprehensive review.Journal of assisted reproduction and genetics · 2025
    Review
  10. Article
  11. Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Scientific opinion on the tolerable upper intake level for manganese.EFSA journal. European Food Safety Authority · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Status of Oxidative Stress during Low-Risk Labour: Preliminary Data.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rima IrwindaMaternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia.
Noroyono WibowoMaternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia.
Atikah Sayogo PutriMaternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia.ORCID 0000-0003-4531-2924
University of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm birth is still a global burden particularly in Indonesia. The suboptimal concentration of certain micronutrients and heavy metals is hypothesized to play a role in the mechanism of preterm birth.

objectiveThis study aimed to analyze the micronutrients and heavy metals concentrations between subjects with term and preterm birth.

designA cross-sectional study was conducted during January-June 2017 in Cipto Mangunkusumo Hospital and Budi Kemuliaan Hospital, Jakarta, Indonesia. Subjects were divided into term and preterm birth groups. The measured outcomes were maternal serum, placental, and blood cord concentration of zinc, copper, iron, selenium, manganese, mercury, lead, AtRA, and 25(OH)D.

resultsA total of 51 pregnant women participated in this study. Term group had higher concentration of maternal serum AtRA (0.22 ± 0.07 ng/mL versus 0.12 ± 0.03 ng/mL, p <0.001), higher placental concentration of manganese {0.99 (0.38 - 1.78)

conclusionPreterm birth is associated with lower concentrations of micronutrients which play a role in antioxidant mechanism, as well as higher concentration of mercury and lead.

Indexed as

AntioxidantsCross-Sectional StudiesFemaleFetal BloodHumansIndonesiaLeadMercuryMetals, HeavyMicronutrientsPlacentaPregnancyPremature BirthAntioxidantsLeadMercuryMetals, HeavyMicronutrients

Identifiers

PMID30693107
PMCPMC6332885
OpenAlexW2907731457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.