Evidence map›Paper›PMID 30693103›Full record

ArticleJournal of ophthalmology2018

Dexamethasone Intravitreal Implant (Ozurdex) for Long-Term Macular Edema after Epiretinal Membrane Peeling Surgery.

Yo-Chen Chang, Pei-Kang Liu, Tzu-En Kao, Horng-Jiun Wu, Kai-Chun Cheng, Kuo-Jen Chen, Kwou-Yeung Wu, Wen-Chuan Wu

Open access · goldAbstract read
In one paragraph

Article in Journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Intravitreal Dexamethasone Implant in Vitreoretinal Surgery: An Overview of the Literature.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Evaluation of intraoperative slow-release dexamethasone implant combined with idiopathic epiretinal membrane removal.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Observational
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yo-Chen ChangDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.ORCID 0000-0001-8751-3148
Pei-Kang LiuDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.ORCID 0000-0002-6417-4363
Tzu-En KaoDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.ORCID 0000-0002-5885-2316
Horng-Jiun WuDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Kai-Chun ChengDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Kuo-Jen ChenDepartment of Ophthalmology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.ORCID 0000-0003-0733-5017
Kwou-Yeung WuDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.ORCID 0000-0003-4171-7270
Wen-Chuan WuDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.ORCID 0000-0001-5930-834X
Kaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the functional and anatomical outcome of the 0.7 mg dexamethasone (Ozurdex) intravitreal implant (IVD) in eyes with long-term macular edema after macular epiretinal membrane removal.

methodsWe enrolled 40 eyes with persistent macular edema at least 12 months after epiretinal membrane removal. Twenty eyes in the IVD group received IVD and the other 20 eyes were in the control group. The main outcome measures were change in best-corrected visual acuity (BCVA) and central foveal thickness (CFT).

resultsFor eyes in the IVD group, the mean BCVA improved by 3.45 lines to 0.47 logMAR one month after IVD. However, the mean BCVA improved by only 0.14 lines to 0.74 logMAR at the same time in eyes in the control group. Six months later, the mean BCVA improved to 0.31 and 0.74 logMAR in the IVD and control groups, respectively. In the IVD group, the mean CFT decreased rapidly by 116.8

conclusionsSingle IVD could significantly decrease macular edema and improve visual outcome for eyes with persistent long-term macular edema after macular ERM removal and the effect can be sustained as long as 6 months after the initial injection. However, in order to maintain the visual and anatomical outcome, repeat IVD might be considered if macular edema recurs.

Identifiers

PMID30693103
PMCPMC6332950
OpenAlexW2905354324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.