ArticleFrontiers in genetics2018
Genome-Wide Gene-Environment Interaction Analysis Using Set-Based Association Tests.
Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations.Nutrition reviews · 2025Pooled it
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies.G3 (Bethesda, Md.) · 2025Article
- Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.Journal of the American Heart Association · 2024Article
- Efficient gene-environment interaction testing through bootstrap aggregating.Scientific reports · 2023Article
- Analytical Approaches to Uncover Genetic Associations for Rare Outcomes: Lessons from West Nile Neuroinvasive Disease.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan.Frontiers in genetics · 2022Article
- SNPxE: SNP-environment interaction pattern identifier.BMC bioinformatics · 2021Article
- Prediction of Early Childhood Caries Based on Single Nucleotide Polymorphisms Using Neural Networks.Genes · 2021Article
- Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene.Frontiers in genetics · 2020Article
- Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease.Neuroscience and biobehavioral reviews · 2019Review
- Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of gene-environment interactions (G × E) may eventually guide health-related choices and medical interventions for complex diseases. More powerful methods must be developed to identify G × E. The "adaptive combination of Bayes factors method" (ADABF) has been proposed as a powerful genome-wide polygenic approach to detect G × E. In this work, we evaluate its performance when serving as a gene-based G × E test. We compare ADABF with six tests including the "Set-Based gene-EnviRonment InterAction test" (SBERIA), "gene-environment set association test" (GESAT), etc. With extensive simulations, SBERIA and ADABF are found to be more powerful than other G × E tests. However, SBERIA suffers from a power loss when 50% SNP main effects are in the same direction with the SNP × E interaction effects while 50% are in the opposite direction. We further applied these seven G × E methods to the Taiwan Biobank data to explore gene× alcohol interactions on blood pressure levels. The
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