ArticleJournal of Indian Society of Periodontology
Antioxidant therapy (lycopene and green tea extract) in periodontal disease: A promising paradigm.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease.Frontiers in bioengineering and biotechnology · 2023Pooled it
- In Vitro Evaluation and Network Pharmacology Analysis of the Antimicrobial Activity ofInternational journal of dentistry · 2026Article
- Analysis of Plant-Based and Herbal Therapies in Periodontal Treatment: Clinical Applications, Mechanistic Insights, and Efficacy.Journal of pharmacy & bioallied sciences · 2025Article
- The effect of systemic lycopene supplementation on non-surgical periodontal therapy outcomes: A clinical trial.BDJ open · 2025Article
- Review
- Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options.Current medicinal chemistry · 2024Review
- Article
- Benefits of Natural Antioxidants on Oral Health.Antioxidants (Basel, Switzerland) · 2023Review
- Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review.Microorganisms · 2023Review
- Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients.International journal of environmental research and public health · 2022Review
- Recent progress and perspectives on the relationship between hyperuricemia and periodontitis.Frontiers in immunology · 2022Review
- Impact of Green Tea (The Japanese dental science review · 2021Review
- Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease.International journal of experimental pathology · 2020Article
- Camellia Sinensis Mouthwashes in Oral Care: a Systematic Review.Journal of dentistry (Shiraz, Iran) · 2020Review
- The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights.Antioxidants (Basel, Switzerland) · 2020Review
- A Mediterranean Diet Intervention Reduces the Levels of Salivary Periodontopathogenic Bacteria in Overweight and Obese Subjects.Applied and environmental microbiology · 2020Article
- Effects of vitamin C local application on ligature-induced periodontitis in diabetic rats.Journal of applied oral science : revista FOB · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased oxidative stress has emerged as one of the prime factors in the pathogenesis of periodontitis. Hence, antioxidant therapy may become a promising tool in the treatment of periodontal disease. Uric acid (UA) being a major antioxidant in saliva can be used as a marker to assess the total antioxidant capacity.
aimThe aim of the study was to investigate the influence of orally administered antioxidants (lycopene and green tea extract) on periodontal health and salivary UA levels in gingivitis patients as an adjunct to scaling and root planing (SRP). MATERIALS AND
methodsThirty systemically healthy participants having generalized gingivitis were randomly distributed into two groups. Control group participants received full mouth oral prophylaxis, while test group participants received oral lycopene and green tea extract (CLIK
resultsBoth treatment groups demonstrated statistically highly significant (
conclusionLycopene with green tea extract may prove to be a promising adjunctive prophylactic and therapeutic modality in the treatment of gingivitis patients. However, further studies are needed to evaluate the additive effect of antioxidants with routine oral prophylaxis therapy.
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Registered trials
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