ArticleNature medicine2019
ApoE attenuates unresolvable inflammation by complex formation with activated C1q.
Erratum issuedOpen access · greenAbstract readVideo-Audio Media
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 178 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 1 pooled it
20.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
178 citing papers in PubMed, 1 synthesis or guideline pooled it, 308 citations in OpenAlex.
- An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis.Psychological medicine · 2019Pooled it
- Apolipoprotein E Plasma Concentrations Are Predictive of Recurrent Strokes: Insights From the SPARCL Trial.Journal of the American Heart Association · 2025Trial
- Serum C1q as a Novel Predictive Biomarker for Postoperative Delirium After Acute Type A Aortic Dissection.Immunity, inflammation and disease · 2026Article
- Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity.Immunological reviews · 2026Review
- Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis.Nature cardiovascular research · 2026Article
- Malondialdehyde epitopes exposed on dying cells are potent modulators of complement activity and efferocytosis.Journal of lipid research · 2026Article
- SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain.Science advances · 2026Article
- Shared genetic and molecular architecture between insulin resistance and cognitive performance.medRxiv : the preprint server for health sciences · 2026Article
- Ferritin-ApoE nanocarrier for targeted therapy of neuromyelitis optica spectrum disorder in mice.Journal of neuroinflammation · 2026Article
- ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer's disease and related disorders.Molecular neurodegeneration · 2026Review
- Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.Nature neuroscience · 2026Article
- Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice.Molecular neurodegeneration · 2026Article
- Review
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Early Binding of Anti-Amyloid Antibodies to CAA Drives Complement Activation, Inflammation and ARIA in Mice.bioRxiv : the preprint server for biology · 2026Article
- CD80Cell communication and signaling : CCS · 2026Article
- Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform.Journal of lipid research · 2026Article
- The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease.Journal of internal medicine · 2026Review
- The complement system in Alzheimer's disease: mechanisms, biomarkers, and therapeutic implications.Frontiers in immunology · 2026Review
- Cross-sectional investigation of choroid plexus calcification, cardiovascular risk score, and APOEε4 Status in cognitively normal cohort.Cerebral circulation - cognition and behavior · 2026Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
29 authors at 12 institutions in 5 countries.
Changjun YinInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany. changjun.yin@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-1913-4477
Susanne AckermannLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.ORCID http://orcid.org/0000-0001-8179-5201
Zhe MaInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Sarajo K MohantaInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0000-0001-6144-4092
Chuankai ZhangInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Yuanfang LiInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Sandor NietzscheCentre for Electron Microscopy, Jena University Hospital, Friedrich-Schiller-University of Jena, Jena, Germany.
Martin WestermannCentre for Electron Microscopy, Jena University Hospital, Friedrich-Schiller-University of Jena, Jena, Germany.
Li PengDepartment of Cardiovascular Medicine of Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Desheng HuDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Sai Vineela BonthaDepartment of Surgery, University of Tennessee, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8914-1966
Prasad SrikakulapuCardiovascular Research Center (CVRC), University of Virginia, Charlottesville, VA, USA.
Michael BeerDepartment of Information Technology, University Clinic Jena, Jena, Germany.
Remco T A MegensInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Sabine SteffensInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.
Markus HildnerInstitute for Anatomy II, University Clinic Jena, Jena, Germany.
Luke D HalderLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Hans-Henning EcksteinDepartment for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jaroslav PelisekDepartment for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jochen HermsCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.
Sigrun RoeberCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.
Thomas ArzbergerCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.
Anna BorodovskyAlnylam Pharmaceuticals Cambridge, Cambridge, MA, USA.
Livia HabenichtII. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna and Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.
Christian WeberInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0000-0003-4610-8714
Peter F ZipfelLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.ORCID http://orcid.org/0000-0002-6149-2411
Christine SkerkaLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany. christine.skerka@hki-jena.de.ORCID http://orcid.org/0000-0003-2374-6473
Andreas J R HabenichtInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0000-0003-2901-3027
Ludwig-Maximilians-Universität München · DEJena University Hospital · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DETUM Klinikum · DEGerman Centre for Cardiovascular Research · DEMaastricht University · NLAlnylam Pharmaceuticals (United States) · USAustrian Academy of Sciences · ATMunich Cluster for Systems Neurology · DEUnion Hospital · CNUniversity of Tennessee Health Science Center · USUniversity of Virginia · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apolipoprotein-E (ApoE) has been implicated in Alzheimer's disease, atherosclerosis, and other unresolvable inflammatory conditions but a common mechanism of action remains elusive. We found in ApoE-deficient mice that oxidized lipids activated the classical complement cascade (CCC), resulting in leukocyte infiltration of the choroid plexus (ChP). All human ApoE isoforms attenuated CCC activity via high-affinity binding to the activated CCC-initiating C1q protein (K
Indexed as
AgedAged, 80 and overAmyloid beta-PeptidesAnimalsAntigen-Antibody ComplexAortaApolipoproteins EAtherosclerosisBrainCarotid ArteriesCarotid Artery DiseasesChoroid PlexusCognitive DysfunctionComplement C1qComplement C5Complement Pathway, ClassicalAmyloid beta-PeptidesAntigen-Antibody ComplexApoE protein, humanApolipoproteins EComplement C1qComplement C5Protein IsoformsRNA, Small Interfering
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