Evidence map›Paper›PMID 30692671›Full record

ArticleNature microbiology2019

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein.

Atsushi Taguchi, Michael A Welsh, Lindsey S Marmont, Wonsik Lee, Megan Sjodt, Andrew C Kruse, Daniel Kahne, Thomas G Bernhardt, Suzanne Walker

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed
36.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 337 citations in OpenAlex.

  1. Drug-likeness prioritised selection identifies anti-Journal of enzyme inhibition and medicinal chemistry · 2026
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  13. Infection and immunity · 2026
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  16. Defining the order of assembly of thebioRxiv : the preprint server for biology · 2026
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  18. Gene Silencing by CRISPR Interference in Fusobacterium nucleatum.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  19. Article
  20. Article

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Atsushi TaguchiDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Michael A WelshDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8268-6285
Lindsey S MarmontDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Wonsik LeeDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
Megan SjodtDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1467-1222
Daniel KahneDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Thomas G BernhardtDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. thomas_bernhardt@hms.harvard.edu.ORCID http://orcid.org/0000-0003-3566-7756
Suzanne WalkerDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. suzanne_walker@hms.harvard.edu.ORCID http://orcid.org/0000-0002-0545-914X
Harvard University · USHoward Hughes Medical Institute · US

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2M
Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Mechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9M
Identifying and validating new antibiotic targets in cell wall synthesis pathwaysR01AI099144 · NIAID · HARVARD MEDICAL SCHOOL · PI BERNHARDT, THOMAS G, WALKER, SUZANNE · 2012 to 2016
$4.3M
Biochemical characterization of LMW PBPS with novel transpeptidase activityF32GM123579 · NIGMS · HARVARD MEDICAL SCHOOL · PI WELSH, MICHAEL AVERY · 2017 to 2019
$130k
NIAID NIH HHS R01 AI083365NIAID NIH HHS R01 AI099144NIAID NIH HHS U19 AI109764NIGMS NIH HHS F32 GM123579NIGMS NIH HHS R01 GM076710
6 · The paper itself

Abstract

The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria

Indexed as

Bacterial ProteinsCell DivisionCell WallMembrane ProteinsPenicillin-Binding ProteinsPeptidoglycanProtein BindingStaphylococcus aureusStreptococcus thermophilusBacterial ProteinsFtsW protein, BacteriaMembrane ProteinsPenicillin-Binding ProteinsPeptidoglycan

Identifiers

PMID30692671
PMCPMC6430707
OpenAlexW2912238261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.