Evidence map›Paper›PMID 30692668›Full record

ArticleNature microbiology2019

Pseudogene repair driven by selection pressure applied in experimental evolution.

Amitesh Anand, Connor A Olson, Laurence Yang, Anand V Sastry, Edward Catoiu, Kumari Sonal Choudhary, Patrick V Phaneuf, Troy E Sandberg, Sibei Xu, Ying Hefner and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Aerobicity stimulon iniScience · 2026
    Article
  3. Review
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  13. Article
  14. Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amitesh AnandDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3720-4301
Connor A OlsonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Laurence YangDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Anand V SastryDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Edward CatoiuDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Kumari Sonal ChoudharyDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Patrick V PhaneufDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Troy E SandbergDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3240-3659
Sibei XuDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Ying HefnerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Richard SzubinDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Adam M FeistDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8630-4800
Bernhard O PalssonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA. palsson@ucsd.edu.ORCID http://orcid.org/0000-0003-2357-6785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

Indexed as

Directed Molecular EvolutionDNA Mismatch RepairPseudogenesSelection, GeneticCation Transport ProteinsEscherichia coliEscherichia coli ProteinsEvolution, MolecularIronOpen Reading FramesPhylogenyCation Transport ProteinsefeU' protein, E coliEscherichia coli ProteinsIron

Identifiers

PMID30692668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.