ArticleJournal of perinatology : official journal of the California Perinatal Association2019
Probiotics for preterm infants: A National Retrospective Cohort Study.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04977817 (A Prospective/Retrospective Chart Review of the Effects of a Probiotic Dietary Supplement on Days of Total Parenteral Nutrition in Two Neonatal Intensive Care Units), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective/Retrospective Chart Review of the Effects of a Probiotic Dietary Supplement on Days of Total Parenteral Nutrition in Two Neonatal Intensive Care Units
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Internet-Based Interventions for Preventing Premature Birth in Preconceptional Women of Childbearing Age: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Pooled it
- Prophylactic Probiotic Supplementation for Preterm Neonates-A Systematic Review and Meta-Analysis of Nonrandomized Studies.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Navigating the trials of a trial: lessons from ProRIDE on recruitment, retention, and follow-up in rural Africa.Trials · 2026Trial
- Probiotic Human Study Design and Reporting (PRODARE): Recommendations to Improve Research Practice.Advances in nutrition (Bethesda, Md.) · 2026Review
- A Review of Probiotic Interventions for Necrotizing Enterocolitis and Sepsis in Preterm Infants.International journal of molecular sciences · 2026Review
- Incidence of probiotic sepsis and morbidity risk in premature infants: a meta-analysis.Pediatric research · 2025Article
- Probiotics and the Risk of Infection.Clinics in perinatology · 2025Review
- Intermediate vs. High Oxygen Saturation Targets in Preterm Infants: A National Cohort Study.Neonatology · 2025Article
- Article
- State of the Art of Probiotic Use in Neonatal Intensive Care Units in French-Speaking European Countries.Children (Basel, Switzerland) · 2023Article
- Probiotics for prevention of necrotizing enterocolitis: Where do we stand?Seminars in perinatology · 2023Review
- Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research.Pediatric research · 2023Review
- Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis.Frontiers in nutrition · 2021Review
- Safety and efficacy of probiotic administration to preterm infants: ten common questions.Pediatric research · 2020Review
- Probiotic Use and Safety in the Neonatal Intensive Care Unit: A Matched Cohort Study.The Journal of pediatrics · 2020Article
- Probiotics for Prevention of Severe Necrotizing Enterocolitis: Experience of New Zealand Neonatal Intensive Care Units.Frontiers in pediatrics · 2020Article
- Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome.Nature microbiology · 2019Article
- Recent Advances in Prevention and Therapies for Clinical or Experimental Necrotizing Enterocolitis.Digestive diseases and sciences · 2019Review
- Implementation of a probiotic protocol to reduce rates of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. STUDY
designWe conducted a retrospective cohort study of infants < 29 weeks' gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used.
resultsA total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS.
conclusionProphylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.
Indexed as
Identifiers
30692619What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.