Evidence map›Paper›PMID 30692612›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2019

Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis.

Adam K Lewkowitz, Anjlie Gupta, Laura Simon, Bethany A Sabol, Carrie Stoll, Emily Cooke, Roxanne A Rampersad, Methodius G Tuuli

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 8 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 8 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  13. Prediction of anemia at delivery.Scientific reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Adam K LewkowitzDepartment of Obstetrics and Gynecology, Washington University in St. Louis, 4566 Scott Avenue, Campus Box 8064, St. Louis, MO, 63110, USA. lewkowitza@wustl.edu.
Anjlie GuptaWashington University School of Medicine in St. Louis, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Laura SimonBecker Medical Library, Washington University School of Medicine in St. Louis, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-3760-6810
Bethany A SabolDepartment of Obstetrics and Gynecology, Washington University in St. Louis, 4566 Scott Avenue, Campus Box 8064, St. Louis, MO, 63110, USA.
Carrie StollWashington University School of Medicine in St. Louis, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Emily CookeDepartment of Pharmacy, Barnes-Jewish Hospital, One Barnes-Jewish Hospital Plaza, St. Louis, MO, 63110, USA.
Roxanne A RampersadDepartment of Obstetrics and Gynecology, Washington University in St. Louis, 4566 Scott Avenue, Campus Box 8064, St. Louis, MO, 63110, USA.
Methodius G TuuliDepartment of Obstetrics & Gynecology, Indiana University School of Medicine, 550N. University Boulevard, UH 2440, Indianapolis, IN, 46202, USA.
Washington University in St. Louis · USBarnes-Jewish Hospital · USIndiana University School of Medicine

Funding

Optimizing Management of the Second Stage of Labor: Multicenter Randomized TrialU01HD077384 · NICHD · WASHINGTON UNIVERSITY · PI CAHILL, ALISON G, TUULI, METHODIUS GAMUO · 2014 to 2019
$7.8M
NICHD NIH HHS U01 HD077384
6 · The paper itself

Abstract

objectiveTo assess the effect of intravenous versus oral iron on hematologic indices and clinical outcomes for iron-deficiency anemia (IDA) in pregnancy. STUDY

designSearches in Ovid Medline, Embase, SCOPUS, Cochrane Database, and ClinicalTrials.gov identified randomized-controlled trials comparing intravenous to oral iron for treating IDA in pregnancy. Primary outcomes were maternal hematologic indices at delivery. Secondary outcomes were blood transfusion, cesarean delivery, neonatal outcomes, and medication reactions.

resultsOf 15,637 studies, 20 randomized trials met inclusion criteria and were analyzed. Mean hemoglobin at delivery (9 studies: WMD 0.66 g/dL (95% confidence Interval 0.31 -1.02 g/dL)) was significantly higher after intravenous iron therapy. Intravenous iron was associated with higher birthweight (8 studies: WMD 58.25 g (95% CI: 5.57-110.94 g)) but no significant differences in blood transfusion, cesarean delivery, or neonatal hemoglobin. There were fewer medication reactions with intravenous iron (21 studies: RR 0.34% (95% CI: 0.20-0.57)).

conclusionIntravenous iron therapy is associated with higher maternal hemoglobin at delivery with no difference in blood transfusion and fewer mild medication reactions.

Indexed as

Administration, IntravenousAdministration, OralAnemia, Iron-DeficiencyDelivery, ObstetricFemaleFerritinsHemoglobinsHumansIronPregnancyPregnancy Complications, HematologicFerritinsHemoglobinsIron

Identifiers

PMID30692612
OpenAlexW2913606500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.