ArticleNature communications2019
Hierarchical composition of reliable recombinase logic devices.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Promise of Synthetic Biology for Redesigning Plant Architecture.International journal of molecular sciences · 2026Review
- Synthetic circuits for cell ratio control.Nature · 2026Article
- Temperature-Dependent Recombinase-Based Genetic Circuits.International journal of molecular sciences · 2025Article
- Quantum-inspired logic for advanced Transcriptional Programming.Nucleic acids research · 2025Article
- The switch-liker's guide to plant synthetic gene circuits.The Plant journal : for cell and molecular biology · 2025Review
- A history-dependent integrase recorder of plant gene expression with single-cell resolution.Nature communications · 2024Article
- Emergent digital bio-computation through spatial diffusion and engineered bacteria.Nature communications · 2024Article
- Engineering intelligent chassis cells via recombinase-based MEMORY circuits.Nature communications · 2024Article
- Accelerating Genetic Sensor Development, Scale-up, and Deployment Using Synthetic Biology.Biodesign research · 2024Article
- Customizing cellular signal processing by synthetic multi-level regulatory circuits.Nature communications · 2023Review
- An integrase toolbox to record gene-expression during plant development.Nature communications · 2023Article
- Article
- Article
- Computational Methods for the Design of Recombinase Logic Circuits with Adaptable Circuit Specifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Synthetic memory circuits for stable cell reprogramming in plants.Nature biotechnology · 2022Article
- Implementing re-configurable biological computation with distributed multicellular consortia.Nucleic acids research · 2022Article
- SYMBIOSIS: synthetic manipulable biobricks via orthogonal serine integrase systems.Nucleic acids research · 2022Article
- Decoding and recoding plant development.Plant physiology · 2021Review
- Synthetic neural-like computing in microbial consortia for pattern recognition.Nature communications · 2021Article
- 2D printed multicellular devices performing digital and analogue computation.Nature communications · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability and requiring time-consuming optimization. Here we provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, optimized recombinase switches. We apply this framework to build a recombinase logic device family supporting up to 4-input Boolean logic within a multicellular system. This work enables straightforward implementation of multicellular recombinase logic and will support the predictable engineering of several classes of recombinase devices to reliably control cellular behavior.
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