Evidence map›Paper›PMID 30692270›Full record

ArticleMolecular and cellular biology2019

Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation.

Carmen Salvador-Palomeque, Francisco J Sanchez-Luque, Patrick R J Fortuna, Adam D Ewing, Ernst J Wolvetang, Sandra R Richardson, Geoffrey J Faulkner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Carmen Salvador-Palomeque *Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Francisco J Sanchez-Luque *Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Patrick R J FortunaAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Queensland, Australia.
Adam D EwingMater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Ernst J WolvetangAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Queensland, Australia.
Sandra R RichardsonMater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia sandra.richardson@mater.uq.edu.au faulknergj@gmail.com.
Geoffrey J FaulknerMater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia sandra.richardson@mater.uq.edu.au faulknergj@gmail.com.ORCID 0000-0001-5769-4494
The University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells. L1 retrotransposition can also occur in the neuronal lineage and cause somatic mosaicism. Although DNA methylation mediates L1 promoter repression, the temporal pattern of methylation applied to individual RC-L1s during neurogenesis is unclear. Here, we identified a

Indexed as

Cells, CulturedDNA MethylationEmbryo, MammalianGene Expression Regulation, DevelopmentalGerm CellsHumansInduced Pluripotent Stem CellsLong Interspersed Nucleotide ElementsNeurogenesisNeuronsPromoter Regions, GeneticRetroelementsRetroelementsL1LINE-1methylationneurogenesisretrotransposon

Identifiers

PMID30692270
PMCPMC6425141
OpenAlexW2911843816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.