Evidence map›Paper›PMID 30692248›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Inositol polyphosphate multikinase mediates extinction of fear memory.

Jina Park, Francesco Longo, Seung Ju Park, Seulgi Lee, Mihyun Bae, Richa Tyagi, Jin-Hee Han, Seyun Kim, Emanuela Santini, Eric Klann and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.Animals : an open access journal from MDPI · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Jina ParkDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea.
Francesco LongoCenter for Neural Science, New York University, New York, NY 10003.
Seung Ju ParkDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea.
Seulgi LeeDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea.
Mihyun BaeCenter for Synaptic Brain Dysfunctions, Institute for Basic Science, 34141 Daejeon, Korea.
Richa TyagiThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Jin-Hee HanDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea.
Seyun KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 34141 Daejeon, Korea; seyunkim@kaist.ac.kr es3544@cumc.columbia.edu eklann@cns.nyu.edu ssnyder@jhmi.edu.ORCID 0000-0003-0110-9414
Emanuela SantiniDepartment of Neurology, Columbia University, New York, NY 10032; seyunkim@kaist.ac.kr es3544@cumc.columbia.edu eklann@cns.nyu.edu ssnyder@jhmi.edu.
Eric KlannCenter for Neural Science, New York University, New York, NY 10003; seyunkim@kaist.ac.kr es3544@cumc.columbia.edu eklann@cns.nyu.edu ssnyder@jhmi.edu.
Solomon H SnyderThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; seyunkim@kaist.ac.kr es3544@cumc.columbia.edu eklann@cns.nyu.edu ssnyder@jhmi.edu.
Korea Advanced Institute of Science and Technology · KRJohns Hopkins University · USNew York University · USColumbia University · USInstitute for Basic Science · KR

Funding

NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGSR37MH018501 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SNYDER, SOLOMON H. · 1990 to 2009
$11.5M
NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGSR01MH018501 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SNYDER, SOLOMON H. · 1985 to 2019
$10.8M
Translation Regulation in Hippocampal LTP and LTDR01NS047384 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2005 to 2020
$5.2M
Reactive Oxygen Species Signaling in the HippocampusR01NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 2000 to 2012
$4.2M
eIF2alpha Phosphorylation in Synaptic Plasticity, Memory, and Brain DisordersR37NS034007 · NINDS · NEW YORK UNIVERSITY · PI KLANN, ERIC · 2014 to 2020
$3.3M
STRIATAL SPECIFIC ALTERATIONS IN TRANSLATION, SYNAPTIC FUNCTION, AND BEHAVIOR INR00NS087112 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTINI, EMANUELA · 2017 to 2018
$498k
Striatal Specific Alterations in Translation, Synaptic Function, and Behavior inK99NS087112 · NINDS · NEW YORK UNIVERSITY · PI SANTINI, EMANUELA · 2014 to 2015
$163k
OXIDATIVE ACTIVATION OF PKC DURING INDUCTION OF LTPR29NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 1995 to 1999
–
NIMH NIH HHS R01 MH018501NIMH NIH HHS R37 MH018501NINDS NIH HHS K99 NS087112NINDS NIH HHS R00 NS087112NINDS NIH HHS R01 NS034007NINDS NIH HHS R01 NS047384NINDS NIH HHS R29 NS034007NINDS NIH HHS R37 NS034007
6 · The paper itself

Abstract

Inositol polyphosphate multikinase (IPMK), the key enzyme for the biosynthesis of higher inositol polyphosphates and phosphatidylinositol 3,4,5

Indexed as

Extinction, PsychologicalMemoryAnimalsEnzyme ActivationFearGene DeletionMiceMice, KnockoutPhosphotransferases (Alcohol Group Acceptor)ProsencephalonSignal TransductionUp-Regulationinositol polyphosphate multikinasePhosphotransferases (Alcohol Group Acceptor)fear extinctioninositol polyphosphate multikinaselong-term potentiationmemory

Identifiers

PMID30692248
PMCPMC6377498
OpenAlexW2914351026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.