Evidence map›Paper›PMID 30692070›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Millimeter wave exposure induces apoptosis in human melanoma A375 cells

Ruiting Zhao, Yonghong Liu, Sida Liu, Tong Luo, Guangyuan Zhong, Anqi Liu, Qiang Zeng, Xuegang Xin

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In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruiting ZhaoSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Yonghong LiuSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Sida LiuSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Tong LuoSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Guangyuan ZhongSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Anqi LiuSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Qiang ZengSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Xuegang XinSchool of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of millimeter wave (MMW) exposure on apoptosis of human melanoma A375 cells and explore the mechanisms.

methodsThrough electromagnetic field calculation we simulated MMW exposure in cells and calculated the specific absorption rate (SAR). The optimal irradiation parameters were determined according to the uniformity and intensity of the SAR. A375 cells were then exposed to MMV for 15, 30, 60, or 90 min, with or without pretreatment with the caspase-3 inhibitor AC-DEVD-fmk (10 μmol/L) for 1 h at 90 min before the exposure. CCK-8 assay was used to assess the changes in the viability and Annexin-V/ PI staining was used to detect the apoptosis of the cells following the exposures; Western blotting was used to detect the expression of caspase-3 in the cells.

resultsThe results of electromagnetic field calculation showed that for optimal MMV exposure, the incident field needed to be perpendicular to the bottom of the plastic Petri dish with the antenna placed below the dish. CCk-8 assay showed that MMW exposure significantly inhibited the cell viability in a time-dependent manner (

conclusions35.2 GHz millimeter wave irradiation induces apoptosis in A375 cells by activating the caspase-3 protein.

Indexed as

ApoptosisMagnetic Field TherapyCaspase 3Caspase InhibitorsCell Line, TumorCell SurvivalElectromagnetic FieldsEnzyme ActivationHumansMelanomaTime FactorsCaspase 3Caspase Inhibitorsapoptosiselectromagnetic calculationirradiationspecific absorption rate

Identifiers

PMID30692070
PMCPMC6765586
OpenAlexW2990129459

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.