Evidence map›Paper›PMID 30691843›Full record

ReviewThe Journal of surgical research2019

Negative-Pressure Wound Therapy in Infants and Children: A Population-Based Study.

Katherine B Santosa, Matt Keller, Margaret A Olsen, Alexandra M Keane, Erika D Sears, Alison K Snyder-Warwick

Abstract readReview
In one paragraph

Review in The Journal of surgical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katherine B SantosaDivision of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Matt KellerDivision of Infectious Diseases, Department of Internal Medicine, Washington University, St. Louis, Missouri.
Margaret A OlsenDivision of Infectious Diseases, Department of Internal Medicine, Washington University, St. Louis, Missouri.
Alexandra M KeaneWashington University School of Medicine, St. Louis, Missouri.
Erika D SearsSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Alison K Snyder-WarwickDivision of Plastic Surgery, Department of Surgery, Washington University, St. Louis, Missouri. Electronic address: snydera@wustl.edu.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
WASHINGTON UNIVERSITY CER MENTORED CAREER DEVELOPMENT AWARD KM1KM1CA156708 · NCI · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$2.5M
WASHINGTON UNIVERSITY COMPARATIVE EFFECTIVENESS ADMINISTRATIVE DATA REPOSITORYR24HS019455 · AHRQ · WASHINGTON UNIVERSITY · PI FRASER, VICTORIA J. · 2010 to 2010
$969k
Investigation of Terminal Schwann Cell Function in Homeostasis and InjuryK08NS096232 · NINDS · WASHINGTON UNIVERSITY · PI SNYDER-WARWICK, ALISON K · 2017 to 2020
$717k
Molecular Mechanisms of Terminal Schwann Cell Response After Nerve InjuryF32NS098561 · NINDS · WASHINGTON UNIVERSITY · PI SANTOSA, KATHERINE BERNADETTE · 2016 to 2017
$123k
AHRQ HHS R24 HS019455HSRD VA IK2 HX002592NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS KM1 CA156708NINDS NIH HHS F32 NS098561NINDS NIH HHS K08 NS096232
6 · The paper itself

Abstract

backgroundAlthough the safety and benefits of negative-pressure wound therapy (NPWT) have been clearly demonstrated in the adult population, studies evaluating the safety and describing the use of NPWT in the pediatric population have been limited. Given this paucity, the goals of this study were to (1) evaluate the literature dedicated to NPWT use in infants and children and (2) leverage a population-level analysis to describe the experience of NPWT use in the pediatric population. MATERIALS AND

methodsWe performed a literature review and analyzed the Truven Health Analytics MarketScan Commercial Claims Databases from 2006 to 2014 to identify infants and children treated with NPWT. We evaluated patient characteristics, indications, complications before and after NPWT placement, and health care utilization within 30 d of NPWT placement.

resultsWe identified 457 articles, 11 of which fit our inclusion criteria. Most studies (65.2%) were case reports or series with less than 10 patients. In addition, we identified 3184 patients aged younger than of 18 y who were treated with NPWT between 2006 and 2014. Serious incident complications within 30 d after NPWT placement were rare (bleeding 0.6%, septicemia 0.5%, and sepsis 0.5%).

conclusionsDespite the lack of robust studies, NPWT is widely used for many indications and across different ages and providers. Given the low incidence of serious complications, we conclude that NPWT use in infants and children is safe and can be effectively used by different providers spanning surgical and nonsurgical disciplines.

Indexed as

Negative-Pressure Wound TherapyChild, PreschoolHumansInfantPatient Acceptance of Health CarePediatricsAdverse effectsChildrenInfantsNegative-pressure wound therapyTherapeutic useVacuum-assisted closure

Identifiers

PMID30691843
PMCPMC6364568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.