Evidence map›Paper›PMID 30691710›Full record

ReviewClinics in chest medicine2019

Asthma and Corticosteroid Responses in Childhood and Adult Asthma.

Amira Ali Ramadan, Jonathan M Gaffin, Elliot Israel, Wanda Phipatanakul

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in chest medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The functional role of CST1 and CCL26 in asthma development.Immunity, inflammation and disease · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Allergic Asthma in the Era of Personalized Medicine.Journal of personalized medicine · 2022
    Review
  19. Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amira Ali RamadanDivision of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Beth Israel Deaconess Center, Cardiovascular institute, 330 Brookline Avenue, Boston, MA 02215, USA.
Jonathan M GaffinDivision of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
Elliot IsraelHarvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Brigham and Women's Hospital, 15 Francis Street, Boston, MA 02115, USA.
Wanda PhipatanakulDivision of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: Wanda.Phipatanakul@childrens.harvard.edu.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
PATINA - Precision Administration of Treatment in Neutrophilic severe AsthmaUG1HL139124 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT · 2017 to 2022
$2.8M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
School-based air pollution and asthma morbidity in Inner City School ChildrenK23AI106945 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2013 to 2017
$822k
NCATS NIH HHS UL1 TR001102NHLBI NIH HHS U10 HL109172NHLBI NIH HHS UG1 HL139124NIAID NIH HHS K23 AI106945NIAID NIH HHS K24 AI106822NIEHS NIH HHS R01 ES030100
6 · The paper itself

Abstract

Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.

Indexed as

Administration, InhalationAdrenal Cortex HormonesAdultAnti-Asthmatic AgentsAsthmaChildHumansTreatment OutcomeAdrenal Cortex HormonesAnti-Asthmatic AgentsAdult asthmaChildhood asthmaCorticosteroid resistanceCorticosteroid responseInhaled corticosteroids

Identifiers

PMID30691710
PMCPMC6355159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.