Evidence map›Paper›PMID 30691609›Full record

ArticleJournal of comparative pathology2019

Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis?

A J Malbon, M L Meli, E N Barker, A D Davidson, S Tasker, A Kipar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of comparative pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. Immunomodulatory Effects ofInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

A J MalbonInstitute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Switzerland; Graduate School for Cellular and Biomedical Sciences, Bern, Switzerland; Center for Clinical Studies, Switzerland.
M L MeliCenter for Clinical Studies, Switzerland; Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Switzerland.
E N BarkerLangford Vets, Langford House, UK.
A D DavidsonSchool of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, UK.
S TaskerBristol Veterinary School, UK.
A KiparInstitute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Switzerland; Institute of Global Health, Faculty of Health and Life Sciences, University of Liverpool, UK. Electronic address: anja.kipar@uzh.ch.
Center for Business Studies · CHAt Bristol · GBThe Langton Grammar School for Boys · GBUniversity of Bristol · GBUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline infectious peritonitis (FIP) is an almost invariably fatal feline coronavirus (FCoV)-induced disease thought to arise from a combination of viral mutations and an overexuberant immune response. Natural initial enteric FCoV infection may remain subclinical, or result in mild enteric signs or the development of FIP; cats may also carry the virus systemically with no adverse effect. This study screened mesenteric lymph nodes (MLNs), the presumed first site of FCoV spread from the intestine regardless of viraemia, for changes in the transcription of a panel of innate immune response mediators in response to systemic FCoV infection and with FIP, aiming to identify key pathways triggered by FCoV. Cats with and without FIP, the latter with and without FCoV infection in the MLN, were compared. Higher expression levels in FIP were found for toll-like receptors (TLRs) 2, 4 and 8. These are part of the first line of defence and suggest a response to both viral structural proteins and viral nucleic acid. Expression of genes encoding inflammatory cytokines and chemokines, including interleukin (IL)-1β, IL-6, IL-15, tumour necrosis factor (TNF)-α, CXCL10, CCL8, interferon (IFN)-α, IFN-β and IFN-γ, was higher in cats with FIP, consistent with inflammatory pathway activation. Expression of genes encoding transcription factors STAT1 and 2, regulating signalling pathways, particularly of the interferons, was also higher. Among cats without FIP, there were few differences between virus-positive and virus-negative MLNs; however, TLR9 and STAT2 expression were higher with infection, suggesting a direct viral effect. The study provides evidence for TLR involvement in the response to FCoV. This could open up new avenues for therapeutic approaches.

Indexed as

AnimalsCatsCoronavirus, FelineFeline Infectious PeritonitisFemaleInflammation MediatorsLymph NodesMaleMesenteryInflammation Mediatorscytokinesfeline coronavirusmesenteric lymph nodestoll-like receptors

Identifiers

PMID30691609
PMCPMC7094650
OpenAlexW2905294505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.