ReviewParasites & vectors2019
Presence of the point mutations Val1016Gly in the voltage-gated sodium channel detected in a single mosquito from Panama.
Review in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemical control of medically important arthropods in Panama: A systematic literature review of historical efforts.Acta tropica · 2024Pooled it
- Insecticide resistance in larval populations of Aedes aegypti and Aedes albopictus from Panama.Tropical medicine and health · 2026Article
- Profiling insecticide resistance phenotypes and genotypes in Aedes aegypti populations across four regions in Puerto Rico.Scientific reports · 2025Article
- Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations: Lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles.PLoS neglected tropical diseases · 2025Article
- Impact of Aedes aegypti V1016I and F1534C knockdown resistance genotypes on operational interventions.Scientific reports · 2025Article
- Understanding the Global Dynamics of Pyrethroid Resistance-relatedZoological studies · 2025Article
- Widespread geographic distribution of Aedes aegypti (Diptera: Culicidae) kdr variants in Panama.Journal of medical entomology · 2024Article
- Article
- Insecticide resistance status and mechanisms in Aedes aegypti and Aedes albopictus from different dengue endemic regions of Panama.Tropical medicine and health · 2024Article
- Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti.PloS one · 2024Article
- Fitness costs in the presence and absence of insecticide use explains abundance of two common Aedes aegypti kdr resistance alleles found in the Americas.PLoS neglected tropical diseases · 2023Article
- High DDT resistance without apparent association to kdr and Glutathione-S-transferase (GST) gene mutations in Aedes aegypti population at hotel compounds in Zanzibar.PLoS neglected tropical diseases · 2022Article
- Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection inEvolutionary applications · 2021Article
- Article
- The F1534C voltage-sensitive sodium channel mutation confers 7- to 16-fold resistance to pyrethroid insecticides in Aedes aegypti.Pest management science · 2020Article
- Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti.Archives of insect biochemistry and physiology · 2020Review
- Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundIn Panama, arboviroses such as dengue fever, and more recently chikungunya fever and Zika disease, are transmitted by Aedes aegypti and Aedes albopictus. Their control is based on the elimination of breeding sites and fogging with pyrethroid insecticides. However, one of the significant issues derived from the prolonged use of pyrethroid insecticide is the development of resistance mechanisms, such as knockdown resistance or kdr. The objective of this study was to evaluate the presence of kdr mutations in a partial region of the VGSC gene in samples of wild-caught Aedes mosquitoes from different locations of the Metropolitan Region of Panama.
resultsBased on the analysis of 194 sequences of the VGSC gene, two kdr mutations (Ile1011Met and Val1016Gly) were detected in a specimen of Ae. aegypti. The frequency of kdr mutations in the evaluated samples of Ae. aegypti was 0.01.
conclusionsThis study provides evidence for a low frequency of kdr mutations in Ae. aegypti populations in Panama. It is possible that these changes have no impact on vector control interventions. To our knowledge, we report, for the first time in America the Val1016Gly mutation documented in Asia. In general terms, this result is highly relevant to the Aedes Control Programme in Panama since it constitutes a feasible approach for the timely detection of resistance as well as for the development of strategies.
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