Evidence map›Paper›PMID 30691508›Full record

ArticleTrials2019

Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial).

Lucy C Chappell, Marcus Green, Neil Marlow, Jane Sandall, Rachael Hunter, Stephen Robson, Ursula Bowler, Virginia Chiocchia, Pollyanna Hardy, Edmund Juszczak and 4 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Foetal lipoprotein oxidation and preeclampsia.Lipids in health and disease · 2022
    Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Lucy C ChappellKing's College London, London, UK. lucy.chappell@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6219-3379
Marcus GreenAction on Pre-eclampsia, London, UK.
Neil MarlowUniversity College London, London, UK.
Jane SandallKing's College London, London, UK.
Rachael HunterUniversity College London, London, UK.
Stephen RobsonNewcastle University, London, UK.
Ursula BowlerNational Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Virginia ChiocchiaNational Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Pollyanna HardyBirmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Edmund JuszczakNational Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Louise LinsellNational Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Anna PlaczekNational Perinatal Epidemiology Unit Clinical Trials Unit, University of Oxford, Oxford, UK.
Peter BrocklehurstBirmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Andrew ShennanKing's College London, London, UK.
University of Oxford · GBKing's College London · GBCancer Research UK Clinical Trials Unit · GBUniversity College London · GBAction for ME · GBNewcastle University · GB

Funding

Department of Health 12/25/03Department of Health HTA/15/59/06Department of Health RP-2014-05-019National Institute for Health Research 12/25/03
6 · The paper itself

Abstract

backgroundPre-eclampsia is a pregnancy disorder, characterised by hypertension and multisystem complications in the mother. The adverse outcomes of pre-eclampsia include severe hypertension, stroke, renal and hepatic injury, haemorrhage, fetal growth restriction and even death. The optimal time to instigate delivery to prevent morbidity when pre-eclampsia occurs between 34 and 37 weeks' gestation, without increasing problems related to infant immaturity or complications, remains unclear. METHODS/

designThe PHOENIX trial is a non-masked, randomised controlled trial, comparing planned early delivery (with initiation of delivery within 48 h of randomisation) with usual care (expectant management) in women with pre-eclampsia between 34 DISCUSSION: Current practice in the UK at the time of trial commencement for management of pre-eclampsia varies by gestation. Previous trials have shown that in women with pre-eclampsia after 37 weeks of gestion, delivery is initiated, as maternal complications are reduced without increasing fetal risks. Prior to 34 weeks of gestation, usual management aims to prolong pregnancy for fetal benefit, unless severe complications occur, necessitating preterm delivery. This trial aims to address the uncertainty for women where the balance of benefits and risks of delivery compared to expectant management are uncertain. Previous trials in this area have been undertaken, but have not provided a definitive answer, and the research question remains active. The results of this trial are expected to influence clinical practice internationally, through direct adoption and by incorporation into guidelines in countries with similar settings.

trial registrationISRCTN01879376 . Registered on 25 November 2013.

Indexed as

Premature BirthAge FactorsChild DevelopmentChild, PreschoolDelivery, ObstetricEnglandFemaleGestational AgeHumansInfant, NewbornMulticenter Studies as TopicPerinatal DeathPragmatic Clinical Trials as TopicPre-EclampsiaPregnancyTime FactorshypertensionperinatalPre-eclampsiapregnancy

Identifiers

PMID30691508
PMCPMC6350286
OpenAlexW2938408816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.