ArticleHarm reduction journal2019
Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients.
Article in Harm reduction journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Cannabinoid exposure across substance use disorders: Short-term symptom benefits without sustained therapeutic gains in a tier-weighted systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies.Drug and alcohol dependence · 2022Pooled it
- Medical cannabis for the reduction of opioid dosage in the treatment of non-cancer chronic pain: a systematic review.Systematic reviews · 2020Pooled it
- Self-reported cannabis use to manage opioid withdrawal symptoms and reductions in opioid use among people who use unregulated opioids: a cross-sectional analysis.Journal of cannabis research · 2026Article
- Medical cannabis authorization and opioid milligram equivalents over time in patients with chronic pain: a retrospective analysis.Pain medicine (Malden, Mass.) · 2026Article
- Medical Cannabis and Opioid Receipt Among Adults With Chronic Pain.JAMA internal medicine · 2026Article
- Observational
- Mothers and fathers who use medical cannabis: A comparison of sociodemographic characteristics, cannabis use, and health.Drug and alcohol dependence reports · 2025Article
- Article
- Opioid reduction in patients with chronic non-cancer pain undergoing treatment with medicinal cannabis.Pain management · 2025Article
- Conceptualizing 'cannabis harm reduction': lessons learned from cannabis compassion clubs and medical dispensaries in British Columbia (Canada).Harm reduction journal · 2025Article
- The role of prescription opioid and cannabis supply policies on opioid overdose deaths.American journal of epidemiology · 2025Article
- Cannabis use and alcohol-related outcomes among sober living house residents with alcohol use disorders.Drug and alcohol dependence reports · 2025Article
- Article
- Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials.Child and adolescent psychiatry and mental health · 2024Review
- Association of cannabis use with patient-reported pain measures among adults with chronic pain in US states with medical cannabis programs.Regional anesthesia and pain medicine · 2024Article
- Factors Associated with Medical Cannabis Use After Certification: A Three-Month Longitudinal Study.Cannabis and cannabinoid research · 2024Article
- "Everything is kind of the same except my mind is with me": exploring cannabis substitution in a sample of adults in early recovery from an opioid or stimulant addiction.Harm reduction journal · 2024Article
- Trends in U.S. Medical Cannabis Registrations, Authorizing Clinicians, and Reasons for Use From 2020 to 2022.Annals of internal medicine · 2024Article
- Cannabis donation as a harm reduction strategy: a case study.Harm reduction journal · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA 239-question cross-sectional survey was sent out via email in January 2017 to gather comprehensive information on cannabis use from Canadian medical cannabis patients registered with a federally authorized licensed cannabis producer, resulting in 2032 complete surveys.
methodsThe survey gathered detailed demographic data and comprehensive information on patient patterns of medical cannabis use, including questions assessing the self-reported impact of cannabis on the use of prescription drugs, illicit substances, alcohol, and tobacco.
resultsParticipants were 62.6% male (n = 1271) and 91% Caucasian (n = 1839). The mean age was 40 years old, and pain and mental health conditions accounted for 83.7% of all respondents (n = 1700). Then, 74.6% of respondents reported daily cannabis use (n = 1515) and mean amount used per day was 1.5 g. The most commonly cited substitution was for prescription drugs (69.1%, n = 953), followed by alcohol (44.5%, n = 515), tobacco (31.1%, n = 406), and illicit substances (26.6%, n = 136). Opioid medications accounted for 35.3% of all prescription drug substitution (n = 610), followed by antidepressants (21.5%, n = 371). Of the 610 mentions of specific opioid medications, patients report total cessation of use of 59.3% (n = 362).
conclusionsThis study offers a unique perspective by focusing on the use of a standardized, government-regulated source of medical cannabis by patients registered in Canada's federal medical cannabis program. The findings provide a granular view of patient patterns of medical cannabis use, and the subsequent self-reported impacts on the use of opioids, alcohol, and other substances, adding to a growing body of academic research suggesting that increased regulated access to medical and recreational cannabis can result in a reduction in the use of and subsequent harms associated with opioids, alcohol, tobacco, and other substances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.