ArticleMicrobial cell factories2019
Engineering an electroactive Escherichia coli for the microbial electrosynthesis of succinate from glucose and CO
Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 96 citations in OpenAlex.
- Perspectives for Advancing Biotechnological Succinic Acid Production.Microbial biotechnology · 2026Review
- Designing Microbe-Semiconductor Interfaces for Semibiological Photosynthesis.Chemical reviews · 2026Review
- Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Key Technologies of Synthetic Biology in Industrial Microbiology.Microorganisms · 2025Review
- Article
- Succinic Acid Production WithEngineering in life sciences · 2025Article
- Blended nexus molecules promote COScience advances · 2024Article
- Microbial electrosynthesis: opportunities for microbial pure cultures.Trends in biotechnology · 2024Review
- Sustainable Production of Biofuels and Biochemicals via Electro-Fermentation Technology.Molecules (Basel, Switzerland) · 2024Review
- Enhanced bioethanol production by evolved Escherichia coli LGE2-H in a microbial electrolysis cell system.Bioresources and bioprocessing · 2024Article
- On the path to generate electricity from wastewater through genetic engineering ofSynthetic biology (Oxford, England) · 2024Article
- Toward bioproduction of oxo chemicals from CBiotechnology for biofuels and bioproducts · 2022Review
- Extracellular Electrons Powered Microbial COAdvances in biochemical engineering/biotechnology · 2022Article
- Proteomics Reveal the Effect of Exogenous Electrons on ElectroactiveFrontiers in microbiology · 2022Article
- Using structure-function relationships to understand the mechanism of phenazine-mediated extracellular electron transfer iniScience · 2021Article
- Improved production of 2,3-butanediol and isobutanol by engineering electron transport chain in Escherichia coli.Microbial biotechnology · 2021Article
- Electrochemical Microwell Plate to Study Electroactive Microorganisms in Parallel and Real-Time.Frontiers in bioengineering and biotechnology · 2021Article
- Towards Application of Electro-Fermentation for the Production of Value-Added Chemicals From Biomass Feedstocks.Frontiers in chemistry · 2021Review
- Electronic control of redox reactions inside Escherichia coli using a genetic module.PloS one · 2021Article
- Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer.Synthetic and systems biotechnology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElectrochemical energy is a key factor of biosynthesis, and is necessary for the reduction or assimilation of substrates such as CO
resultsIn this research, an electroactive succinate-producing cell factory was engineered in E. coli T110(pMtrABC, pFccA-CymA) by expressing mtrABC, fccA and cymA from Shewanella oneidensis MR-1, which can utilize electricity to reduce fumarate. The electroactive T110 strain was further improved by incorporating a carbon concentration mechanism (CCM). This strain was fermented in an MES system with neutral red as the electron carrier and supplemented with HCO
conclusionsThe strain T110(pMtrABC, pFccA-CymA, pBTCA) is to our best knowledge the first electroactive microbial cell factory engineered to directly utilize electricity for the production of a specific product. Due to the versatility of the E. coli platform, this pioneering research opens the possibility of engineering various other cell factories to utilize electricity for bioproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.