Evidence map›Paper›PMID 30691405›Full record

ArticleBMC geriatrics2019

Effectiveness of an intervention in multicomponent exercise in primary care to improve frailty parameters in patients over 70 years of age (MEFAP-project), a randomised clinical trial: rationale and study design.

M V Castell, A Gutiérrez-Misis, M Sánchez-Martínez, M A Prieto, B Moreno, S Nuñez, R Triano, M P de Antonio, C Mateo, M D Cano and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03568084 (Effectiveness of an Intervention in Multicomponent Exercise), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03568084 naterminatednot on this map

Effectiveness of an Intervention in Multicomponent Exercise (MEFAP) in Patients Over 70 Years in Primary Care: Reversibility of Prefrailty

TypeinterventionalSponsorGerencia de Atención Primaria, MadridRan2018 to 2020Enrolled206ConditionsFrail Elderly, Physical ActivityArmsMEFAP, control usual practice
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

M V CastellDoctor Castroviejo Primary Care Health University Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
A Gutiérrez-MisisMedicine Department, Family Medicine and Primary Care Division, School of Medicine, Autonoma University of Madrid, C/ Arzobispo Morcillo, 2-4, 28049, Madrid, Spain. alicia.gutierrezm@uam.es.
M Sánchez-MartínezHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
M A PrietoValdelasfuentes Primary Care Health Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
B MorenoReina Victoria Primary Care Health University Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
S NuñezTorrelaguna Primary Care Health Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
R TrianoMiraflores Primary Care Health Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
M P de AntonioColmenar Viejo Norte Primary Care Health Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
C MateoFuencarral Primary Care Health University Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
M D CanoMedicine Department, Family Medicine and Primary Care Division, School of Medicine, Autonoma University of Madrid, C/ Arzobispo Morcillo, 2-4, 28049, Madrid, Spain.
A GarridoHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
R JulianDoctor Castroviejo Primary Care Health University Center. Northern Primary Care Health Directorate of the Community of Madrid, Madrid, Spain.
E PolentinosResearch Network in Health Services and Chronic Diseases (REDISSEC), Madrid, Spain.
R Rodriguez-BarrientosResearch Network in Health Services and Chronic Diseases (REDISSEC), Madrid, Spain.
A Otero PuimeHospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
MEFAP Group
Hospital La Paz Institute for Health Research · ESMadrid Health Service · ESCatholic University of Ávila · ESSpanish Clinical Research Network · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical activity may reverse frailty in the elderly, but we encounter barriers to the implementation of exercise programs in this population. Our main aim is to evaluate the effect of a multicomponent physical activity program, versus regular medical practice, on reverting pre-frailty status among the elderly, 12 months post-intervention.

methodsRandomized parallel group multicenter clinical trial located in primary care setting, among non-dependent and pre-frail patients > 70 years old, including 190 patients (95 intervention, 95 control group).

interventionMulticomponent physical activity program (MEFAP, for its acronym in Spanish) with twelve 1.5 h-weekly sessions comprised of: 1. Informative session; 2. Exercises for improving aerobic resistance, muscle strength, propioception-balance and flexibility; and 3. Handing out of at-home exercise chart (twice/week). Main variable: pre-frailty according to the Fried phenotype. Secondary variables: sociodemographic, clinical and functional variables; exercise program adherence, patient satisfaction with the program and quality of life. We will perform an intention-to-treat analysis by comparing the retrogression from pre-frailty (1 or 2 Fried criteria) to robust status (0 Fried criteria) by the end of the intervention, 6 months and 12 months post-intervention. The accumulated incidence in each group will be calculated, as well as the relative risk (RR) and the number needed to treat (NNT) with their corresponding 95% confidence intervals. Protocol was approved by the Ethics Committee Hospital la Paz. DISCUSSION: Within the context of regular clinical practice, our results will provide evidence regarding the effects of exercise interventions on frailty among pre-frail older adults, a key population given their significant potential for functional, physical, and mental health improvement.

trial registrationNCT03568084 . Registered 26 June 2018. Date of enrollment of the first participant to the trial: July 2nd 2018.

Indexed as

Frail ElderlyAgedAged, 80 and overCombined Modality TherapyExerciseExercise TherapyFemaleFrailtyHumansMaleMulticenter Studies as TopicMuscle StrengthPatient SatisfactionPrimary Health CareQuality of LifeRandomized Controlled Trials as TopicElderlyExerciseFrailtyPhysical activityPrimary health careRandomised clinical trial

Identifiers

PMID30691405
PMCPMC6348680
OpenAlexW2918757076

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.