Evidence map›Paper›PMID 30691207›Full record

ReviewInternational journal of molecular sciences2019

The Role of Tumor-Associated Neutrophils in Colorectal Cancer.

Rei Mizuno, Kenji Kawada, Yoshiro Itatani, Ryotaro Ogawa, Yoshiyuki Kiyasu, Yoshiharu Sakai

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 6 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 6 syntheses or guidelines pooled it, 313 citations in OpenAlex.

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138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rei MizunoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. reimzn@kuhp.kyoto-u.ac.jp.
Kenji KawadaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. kkawada@kuhp.kyoto-u.ac.jp.ORCID 0000-0003-4336-6937
Yoshiro ItataniDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. itatani@kuhp.kyoto-u.ac.jp.ORCID 0000-0001-7356-7065
Ryotaro OgawaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. ogawaryo@kuhp.kyoto-u.ac.jp.
Yoshiyuki KiyasuDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. ykiyasu@kuhp.kyoto-u.ac.jp.
Yoshiharu SakaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. ysakai@kuhp.kyoto-u.ac.jp.
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and the number of CRC patients is increasing progressively. Despite the improvement of the surgical techniques and chemotherapy, we have not completely overcome this disease yet due to the metastases. Therefore, understanding the mechanisms through which metastasis occurs is important for overcoming CRC. Normal host cells in the tumor microenvironment, such as macrophages and fibroblasts, have been reported to promote the growth of CRCs. Although neutrophils were originally considered to have defensive functions against tumor cells, it has been revealed that some populations of neutrophils, called as tumor-associated neutrophils (TANs), have tumor-supportive functions. The plasticity between tumor-suppressive and -supportive neutrophils are regulated by transforming growth factor (TGF)-β and Interferon-β signaling. Some studies have demonstrated that TANs promote the spread of cancer cells to distant organs. TANs contribute to the tumor invasion and angiogenesis through the production of matrix metalloproteinase-9 (MMP9), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) in the primary and metastatic sites. Neutrophils also promotes tumor cell dissemination by capturing circulating tumor cells using neutrophil extracellular traps and promote their migration to distant sites. The neutrophil-to-lymphocyte ratio is a well-defined predictive marker for CRC patients. In this review, we highlight the molecular signaling between TANs and CRC cells and the possibility of TANs as a potential target for cancer therapy.

Indexed as

Colorectal NeoplasmsHepatocyte Growth FactorHumansInterferon-betaMatrix Metalloproteinase 9Neoplasm InvasivenessNeutrophilsSignal TransductionTransforming Growth Factor betaTumor MicroenvironmentVascular Endothelial Growth Factor AHepatocyte Growth FactorHGF protein, humanInterferon-betaMatrix Metalloproteinase 9MMP9 protein, humanTransforming Growth Factor betaVascular Endothelial Growth Factor AVEGFA protein, humancancer immunitycolon cancerneutrophilstumor microenvironment

Identifiers

PMID30691207
PMCPMC6386937
OpenAlexW2912016163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.