Evidence map›Paper›PMID 30691112›Full record

ArticleMolecules (Basel, Switzerland)2019

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria.

Aneta Kaczor, Karolina Witek, Sabina Podlewska, Joanna Czekajewska, Annamaria Lubelska, Ewa Żesławska, Wojciech Nitek, Gniewomir Latacz, Sandrine Alibert, Jean-Marie Pagès and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria.Current topics in medicinal chemistry · 2022
    Article
  7. Article
  8. Article
  9. Design and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Aneta KaczorDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. aneta.kaczor@student.uj.edu.pl.
Karolina WitekDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. karolina.witek@uj.edu.pl.
Sabina PodlewskaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. smusz@if-pan.krakow.ORCID 0000-0002-2891-5603
Joanna CzekajewskaDepartment of Pharmaceutical Microbiology; Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. j.czekajewska@uj.edu.pl.
Annamaria LubelskaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. annamarialubelska@outlook.com.
Ewa ŻesławskaDepartment of Chemistry, Institute of Biology, Pedagogical University of Cracow, Podchorążych 2, 30-084 Cracow, Poland. ewa.zeslawska@up.krakow.pl.ORCID 0000-0003-1946-9370
Wojciech NitekFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Cracow, Poland. nitek@chemia.uj.edu.pl.
Gniewomir LataczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. glatacz@cm-uj.krakow.pl.ORCID 0000-0001-9247-2598
Sandrine AlibertAix Marseille Univ, INSERM, SSA, MCT, FAC PHARM, 27 Bd Jean Moulin, 13005 Marseille, France. sandrine.alibert@univ-amu.fr.ORCID 0000-0001-5811-0139
Jean-Marie PagèsAix Marseille Univ, INSERM, SSA, MCT, FAC PHARM, 27 Bd Jean Moulin, 13005 Marseille, France. Jean-Marie.PAGES@univ-amu.fr.
Elżbieta KarczewskaDepartment of Pharmaceutical Microbiology; Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. elzbieta.karczewska@uj.edu.pl.
Katarzyna Kieć-KononowiczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. mfkonono@cyf-kr.edu.pl.
Jadwiga HandzlikDepartment of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Cracow, Poland. j.handzlik@uj.edu.pl.
Jagiellonian University · PLInserm · FRUniwersytet Komisji Edukacji Narodowej w Krakowie · PL

Funding

National Statutory Research Project K/ZDS/007886Polish Ministry of Science 0169/DIA/2017/46
6 · The paper itself

Abstract

Searching for new chemosensitizers of bacterial multidrug resistance (MDR), chemical modifications of (Z)-5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-4(5H)-one (

Indexed as

AminesAnti-Bacterial AgentsBacteriaBacterial ProteinsDrug Resistance, Multiple, BacterialHumansHydrogen BondingImidazolesMicrobial Sensitivity TestsModels, MolecularMolecular StructureStructure-Activity RelationshipAminesAnti-Bacterial AgentsBacterial ProteinsImidazolesimidazolone5-arylideneimidazolonesADMET in vitroallosteric modulationEfflux pumpEnterobacter aerogenesmicrodilution assaysMRSAmulti-drug resistanceRTE studiesStaphylococcus aureus

Identifiers

PMID30691112
PMCPMC6384991
OpenAlexW2913231596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.