ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2019
Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveMyostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression.
methodsTwenty-nine patients with treatment resistant major depression and thirty healthy volunteers were included in the study. Pre- and post-ECT levels of myostatine were compared; also this results were compared to healthy controls.
resultsFor 29 patients with treatment-resistant major depression, the pre-treatment mean myostatin level was 0.95±0.32 ng/ml and post-therapy myostatin level was 11.05±6.97 ng/ml. As a result of this study, it is found that ECT affects serum myostatin levels to a significant degree (t=4.17,
conclusionWith the present study and similar ones, it can be understood that how ECT achieves its effectiveness biologically.
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