Evidence map›Paper›PMID 30690734›Full record

ArticleImmunology2019

Sialomucin CD43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration.

Francisco E Velázquez, Marina Anastasiou, Francisco J Carrillo-Salinas, Njabulo Ngwenyama, Ane M Salvador, Tania Nevers, Pilar Alcaide

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Mechanisms Regulating T Cell-Endothelial Cell Interactions.Cold Spring Harbor perspectives in medicine · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Francisco E VelázquezDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Marina AnastasiouDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Francisco J Carrillo-SalinasDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Njabulo NgwenyamaDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Ane M SalvadorDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Tania NeversDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Pilar AlcaideDepartment of Immunology, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0003-3013-3982
Tufts University · US

Funding

IMMUNOLOGIC ASPECTS OF DISEASET32AI007077 · NIAID · TUFTS UNIVERSITY BOSTON · PI WORTIS, HENRY H. · 1985 to 2017
$3.5M
T Cell Mediated Immune Responses as a Regulator of Heart FailureR01HL123658 · NHLBI · TUFTS UNIVERSITY BOSTON · PI ALCAIDE ALONSO, MARIA PILAR · 2014 to 2018
$2.2M
Simultaneous Assay for Multiple Pathogens in Blood (SAMP-B)R44HL097406 · NHLBI · MAXWELL SENSORS, INC. · PI CHEN, GAO · 2012 to 2013
$990k
Endothelial regulation of IL17 producing T effector cell migrationR00HL094706 · NHLBI · TUFTS MEDICAL CENTER · PI ALCAIDE ALONSO, MARIA PILAR · 2011 to 2013
$735k
Simultaneous Assay for Multiple Pathogens in Blood (SAMP-B)R43HL097406 · NHLBI · MAXWELL SENSORS, INC. · PI CHEN, GAO · 2009 to 2009
$200k
NHLBI NIH HHS R01 HL123658NHLBI NIH HHS R43 HL097406NHLBI NIH HHS R44 HL097406NIAID NIH HHS T32 AI007077NIH HHS HL097406NIH HHS HL123658NIH HHS HL123658-01S1NIH HHS T32AI007077-34
6 · The paper itself

Abstract

T helper type 17 lymphocytes (Th17 cells) infiltrate the central nervous system (CNS), induce inflammation and demyelination and play a pivotal role in the pathogenesis of multiple sclerosis. Sialomucin CD43 is highly expressed in Th17 cells and mediates adhesion to endothelial selectin (E-selectin), an initiating step in Th17 cell recruitment to sites of inflammation. CD43

Indexed as

AnimalsCell AdhesionCell MovementDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalHumansInflammationIntercellular Adhesion Molecule-1LeukosialinLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMultiple SclerosisTh17 CellsTransendothelial and Transepithelial MigrationIcam1 protein, mouseIntercellular Adhesion Molecule-1LeukosialinVascular Cell Adhesion Molecule-1autoimmunityCD43intercellular adhesion molecule 1leukocyte recruitmentT helper type 17 cells

Identifiers

PMID30690734
PMCPMC6459779
OpenAlexW2911809930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.