ReviewDevelopmental psychobiology2019
Is adolescence the missing developmental link in Microbiome-Gut-Brain axis communication?
Review in Developmental psychobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Constipation is associated with an increased risk of depression: A systematic review and meta-analysis of observational studies.Translational psychiatry · 2026Pooled it
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- Irritable bowel syndrome and suicide risk among adolescents: a prospective cohort study.The Lancet regional health. Western Pacific · 2026Article
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Article
- Adult Rome IV Disorders of Gut-Brain Interaction in a Pediatric Population.Children (Basel, Switzerland) · 2026Article
- New Trends and Challenges in Academic Research on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Gut microbiota dysbiosis in adolescent depression: a comparative analysis with adult depression and healthy adolescent.Frontiers in microbiology · 2026Article
- Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents.Microbiome · 2025Article
- Article
- Investigating bidirectional causal relationships between gut microbiota and insomnia.General psychiatry · 2025Article
- The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.Brain, behavior, & immunity - health · 2024Article
- Identifying Microbiome Dynamics in Pediatric IBD: More than a Family Matter.Biomedicines · 2023Article
- The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers.EBioMedicine · 2023Article
- The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment.Brain, behavior, & immunity - health · 2022Article
- Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation.Frontiers in cellular and infection microbiology · 2022Review
- The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.Nutrients · 2021Review
- A biological framework for emotional dysregulation in alcohol misuse: from gut to brain.Molecular psychiatry · 2021Review
- Nested sensitive periods: how plasticity across the microbiota-gut-brain axis interacts to affect the development of learning and memory.Current opinion in behavioral sciences · 2020Article
- Sensitive phases in the development of rodent social behavior.Current opinion in behavioral sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Gut microbial research has recently opened new frontiers in neuroscience and potentiated novel therapies for mental health problems (Mayer, et al., 2014). Much of our understanding of the gut microbiome's role in brain function and behavior, however, has been largely derived from research on nonhuman animals. Even less is known about how the development of the gut microbiome influences critical periods of neural and behavioral development, particularly adolescence. In this review, we first discuss why the gut microbiome has become increasingly relevant to developmental cognitive neuroscience and provide a synopsis of the known connections of the gut microbiome with social-affective brain function and behavior, specifically highlighting human developmental work when possible. We then focus on adolescence, a key period of neurobiological and social-affective development. Specifically, we review the links between the gut microbiome and six overarching domains of change during adolescence: (a) social processes, (b) motivation and behavior, (c) neural development, (d) cognition, (e) neuroendocrine function, and (f) physical health and wellness. Using a developmental science perspective, we summarize key changes across these six domains to underscore the promise for the gut microbiome to bidirectionally influence and transform adolescent development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.