ArticleAnnals of biomedical engineering2019
Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage.
Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Shear Strain Stiffening in Cartilage is Governed by a Mechanical Phase Transition.bioRxiv : the preprint server for biology · 2026Article
- Cationic Tantalum Oxide Nanoparticle and Neutral Iodixanol Contrast Agents Alter Cartilage Mechanical Properties.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling.Annals of biomedical engineering · 2026Article
- Degeneration dependent changes in human knee cartilage mechanical properties revealed by synchrotron tomography based finite element modeling.Osteoarthritis and cartilage open · 2026Article
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- Permeability of bone and cartilage, and stiffness of collagen within cartilage, influence osteochondral fluid transport during cyclic compression: A study in finite elements.Journal of the mechanical behavior of biomedical materials · 2026Article
- Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis.Scientific reports · 2026Article
- A sulfonated cartilage interpenetrating polymer network reinforces and protects the extracellular matrix of degraded cartilage.Acta biomaterialia · 2026Article
- Article
- A new device and method for detecting the permeability of articular cartilage.Frontiers in bioengineering and biotechnology · 2026Article
- Depth-Wise Changes in Tibial and Femoral Human Knee Joint Cartilage at Different Severities of Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Development and tribological characterization of polyvinyl alcohol-based artificial cartilage forFrontiers in bioengineering and biotechnology · 2026Article
- Engineering biomimetic zonal properties in fibre-reinforced hydrogels for functional cartilage tissue engineeringMaterials today. Bio · 2025Article
- Cartilage mechanical responses during gait as in silico biomarkers for medial knee OA progression.Scientific reports · 2025Article
- Assessment of CA4+ Impact on Mechanical Properties of Articular Cartilage.Materials (Basel, Switzerland) · 2025Article
- Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective.Bioengineering (Basel, Switzerland) · 2025Review
- Raman spectroscopic probe provides optical biomarkers of cartilage composition predictive of tissue function.Osteoarthritis and cartilage · 2025Article
- The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue.Journal of biophotonics · 2025Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity.Annals of biomedical engineering · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Articular cartilage constituents (collagen, proteoglycans, fluid) are significantly altered during osteoarthritis (OA). A fibril-reinforced poroelastic (FRPE) material model can separate the contribution of each constituent on the mechanical response of cartilage. Yet, these properties and their OA related alterations are not known for human tibial cartilage. To answer this gap in the knowledge, we characterized the FRPE as well as elastic and viscoelastic properties of healthy and osteoarthritic human tibial cartilage. Tibial osteochondral explants (n = 27) harvested from 7 cadavers were mechanically tested in indentation followed by a quantification of elastic, viscoelastic and FRPE properties. Then they were histopathologically OARSI graded for the severity of OA. FRPE modeling revealed that non-fibrillar matrix modulus was higher in the healthy group compared to the early OA (p = 0.003) and advanced OA (p < 0.001) groups. The initial fibril network modulus was also higher in the healthy group compared to the early OA (p = 0.009) and advanced OA (p < 0.001) groups. The permeability correlated with the OARSI grade (p = 0.002, r = 0.56). For the first time, the FRPE properties were characterized for human tibial cartilage. This knowledge is crucial to improve the accuracy of computational knee joint models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.