Evidence map›Paper›PMID 30690684›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Frequency of low-grade adverse events and quality of life during chemotherapy determine patients' judgement about treatment in advanced-stage thoracic cancer.

Mark de Mol, Sabine Visser, Brenda L den Oudsten, Paul Lodder, Nico van Walree, Huub Belderbos, Joachim G Aerts

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Real-world data of the association between quality of life using the EuroQol 5 Dimension 5 Level utility value and adverse events for outpatient cancer chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark de MolDepartment of Pulmonary Diseases, Amphia Hospital, P.O. Box 90158, 4800 RK, Breda, The Netherlands.
Sabine VisserDepartment of Pulmonary Diseases, Amphia Hospital, P.O. Box 90158, 4800 RK, Breda, The Netherlands.
Brenda L den OudstenDepartment of Medical and Clinical Psychology, Centre of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, P.O. Box 90151, 5000 LE, Tilburg, The Netherlands.
Paul LodderDepartment of Medical and Clinical Psychology, Centre of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, P.O. Box 90151, 5000 LE, Tilburg, The Netherlands.
Nico van WalreeDepartment of Pulmonary Diseases, Amphia Hospital, P.O. Box 90158, 4800 RK, Breda, The Netherlands.
Huub BelderbosDepartment of Pulmonary Diseases, Amphia Hospital, P.O. Box 90158, 4800 RK, Breda, The Netherlands.
Joachim G AertsDepartment of Pulmonary Diseases, Amphia Hospital, P.O. Box 90158, 4800 RK, Breda, The Netherlands. j.aerts@erasmusmc.nl.

Funding

ZonMw 152001017
6 · The paper itself

Abstract

purposeIn lung cancer, the preservation of well-being is warranted given the limited prognosis. Chemotherapy may negatively influence health-related quality of life (HRQoL) due to adverse events. However, patients' judgement about this negative impact is not well understood. We examined the relationship between expectations, feelings about side effects, and satisfaction with therapy and (HR)QoL in advanced-stage thoracic cancer and investigated which of these factors has the highest impact on (HR)QoL.

methodsSixty-nine patients completed the Cancer Therapy Satisfaction Questionnaire (CTSQ), the World Health Organization Quality of Life-BREF (WHOQOL-BREF), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Multiple regression analyses were performed to investigate the relation of the CTSQ domains (i.e., expectations of therapy, feelings about side effects, satisfaction with therapy) with (HR)QoL and simple regression analyses to identify the factors of the CTSQ domain that was most often associated with (HR)QoL.

resultsFeelings about side effects were associated with the (HR)QoL domain/scale scores (i.e., WHOQOL-BREF domains: β = 0.36 to 0.58; EORTC QLQ-C30 scales: β = 0.33 to 0.61) except social relationships of the WHOQOL-BREF. Low-grade adverse events were related to feelings about side effects (β = - 0.326; P = 0.007).

conclusionsPatients experiencing negative feelings about side effects have worse (HR)QoL. Additional care should be provided to prevent low-grade adverse events.

Indexed as

AdultAgedAntineoplastic AgentsCarcinoma, Non-Small-Cell LungDrug-Related Side Effects and Adverse ReactionsEmotionsFemaleHealth StatusHumansLung NeoplasmsMaleMiddle AgedPatient SatisfactionPersonal SatisfactionQuality of LifeSurveys and QuestionnairesAntineoplastic AgentsAdverse eventsAnti-neoplastic therapyCancer Therapy Satisfaction QuestionnaireNon-small cell lung cancerPsycho-oncology

Identifiers

PMID30690684
PMCPMC6660482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.