Evidence map›Paper›PMID 30690666›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study.

Victor L Villemagne, D Velakoulis, V Doré, S Bozinoski, C L Masters, C C Rowe, Mark Walterfang

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Neuropsychological assessment in Niemann-Pick disease type C: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Victor L VillemagneDepartment of Molecular Imaging & Therapy, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic, 3084, Australia. victorlv@unimelb.edu.au.ORCID http://orcid.org/0000-0002-5832-9875
D VelakoulisNeuropsychiatry Unit, Royal Melbourne Hospital & Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, 3050, Australia.
V DoréDepartment of Molecular Imaging & Therapy, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic, 3084, Australia.
S BozinoskiDepartment of Molecular Imaging & Therapy, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic, 3084, Australia.
C L MastersThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
C C RoweDepartment of Molecular Imaging & Therapy, Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Vic, 3084, Australia.
Mark WalterfangThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. mark.walterfang@mh.org.au.
The Royal Melbourne Hospital · AUThe University of Melbourne · AUAustin Health · AUAustralian e-Health Research Centre · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

Austin Hospital Medical Research Foundation N/A
6 · The paper itself

Abstract

purposeNiemann-Pick type C (NPC) is a cholesterol storage disease characterized by disruption in the endosomal-lysosomal transport system that leads to the accumulation of cholesterol and glycolipids in lysosomes. Developmental cognitive delay and progressive motor and cognitive impairment are characteristic of the disease. Tau accumulation has been reported in some NPC patients. We investigated the presence of tau and Aβ-amyloid deposits in a group of NPC patients and for comparison in age-matched healthy controls (HC).

methodsEight NPC patients and seven HC were included in the study. Participants underwent tau imaging with

resultsAll participants were Aβ-negative. Four NPC patients presented with high tau burden in the brain. A 21-year-old female patient and a 40-year-old male patient showed high neocortical tau burden in a pattern different from that observed in patients with Alzheimer's disease, while the same 40-year-old male patient, a 40-year-old female patient and a 50-year-old female patient showed high regional tau burden in the mesial temporal cortex. Spearman's correlation analysis showed an association between tau burden in the mesial temporal lobe and age (p = 0.022), and age at symptom onset (p = 0.009), and between frontotemporal tau and duration of symptoms (p = 0.027). There were no correlations between global and regional tau and cognitive parameters.

conclusionFour of eight NPC patients showed tau deposition in the brain. The results of our exploratory study suggest that while tau deposits do not affect cognitive performance, tau deposits are associated with measures of disease onset and progression. Further studies in a larger cohort of NPC patients are needed to confirm these initial findings.

Indexed as

Magnetic Resonance ImagingAdolescentAdultCase-Control StudiesFemaleHumansMaleMiddle AgedNiemann-Pick Disease, Type Ctau ProteinsYoung Adulttau ProteinsAmyloid imagingCognitive impairmentDisease severityNiemann-Pick type C diseaseTau imagingTau pathology

Identifiers

PMID30690666
OpenAlexW2913381908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.