Evidence map›Paper›PMID 30690654›Full record

ReviewJournal of assisted reproduction and genetics2019

Artificial intelligence and machine learning for human reproduction and embryology presented at ASRM and ESHRE 2018.

Carol Lynn Curchoe, Charles L Bormann

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07611448 (An Observational Study of Artificial Intelligence-Assisted Blastocyst Morphokinetic Analysis Using Short-Duration Video and Its Association With Pregnancy Outcomes), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07611448 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

An Observational Study of Artificial Intelligence-Assisted Blastocyst Morphokinetic Analysis Using Short-Duration Video and Its Association With Pregnancy Outcomes

Typeobservational_patient_registrySponsorViable BiosciencesRan2026 to 2029Enrolled1,000ConditionsInfertility Assisted Reproductive Technology, Infertility (IVF Patients)
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. SART CORS IVF registry: looking to the past to shape future perspectives.Journal of assisted reproduction and genetics · 2022
    Pooled it
  2. Review
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  13. A review of artificial intelligence applications in in vitro fertilization.Journal of assisted reproduction and genetics · 2025
    Review
  14. Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carol Lynn CurchoeSan Diego Fertility Center, 11425 El Camino Real, San Diego, CA, 92130, USA. carolcurchoe@32atps.com.
Charles L BormannDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sixteen artificial intelligence (AI) and machine learning (ML) approaches were reported at the 2018 annual congresses of the American Society for Reproductive Biology (9) and European Society for Human Reproduction and Embryology (7). Nearly every aspect of patient care was investigated, including sperm morphology, sperm identification, identification of empty or oocyte containing follicles, predicting embryo cell stages, predicting blastocyst formation from oocytes, assessing human blastocyst quality, predicting live birth from blastocysts, improving embryo selection, and for developing optimal IVF stimulation protocols. This represents a substantial increase in reports over 2017, where just one abstract each was reported at ASRM (AI) and ESHRE (ML). Our analysis reveals wide variability in how AI and ML methods are described (from not at all or very generic to fully describing the architectural framework) and large variability on accepted dataset sizes (from just 3 patients with 16 follicles in the smallest dataset to 661,060 images of 11,898 human embryos in one of the largest). AI and ML are clearly burgeoning methodologies in human reproduction and embryology and would benefit from early application of reporting standards.

Indexed as

Embryonic DevelopmentArtificial IntelligenceBlastocystFemaleFertilization in VitroHumansMachine LearningOocytesPregnancyPregnancy OutcomeReproductive Techniques, AssistedArtificial intelligenceASHREASRMEmbryologyHuman reproductionMachine learning

Identifiers

PMID30690654
PMCPMC6504989

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.