ArticlePain medicine (Malden, Mass.)2019
Impairment of Inhibition of Trigeminal Nociception via Conditioned Pain Modulation in Persons with Migraine Headaches.
Article in Pain medicine (Malden, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM).The journal of headache and pain · 2024Pooled it
- Characterising the Features of 381 Clinical Studies Evaluating Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Relief: A Secondary Analysis of the Meta-TENS Study to Improve Future Research.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- OnabotulinumtoxinA inhibits dysregulation of descending pain modulation following mild traumatic brain injury in mice.The journal of headache and pain · 2025Article
- Investigation of Sensory and Neuropsychological Parameters in Migraine Sufferers: A Cross-Sectional Study with Negative Findings.Neurology and therapy · 2025Article
- Diffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies.International journal of molecular sciences · 2025Review
- Investigating the effects of artificial baroreflex stimulation on pain perception: A comparative study in no-pain and chronic low back pain individuals.The Journal of physiology · 2024Article
- A Systematic Review and Meta-Analysis of Conditioned Pain Modulation in Children and Young People with Chronic Pain.Children (Basel, Switzerland) · 2024Review
- Endogenous pain modulation after sleep restriction in migraine: a blinded crossover study.The journal of headache and pain · 2024Article
- Posttraumatic headache: pain related evoked potentials (PREP) and conditioned pain modulation (CPM) to assess the pain modulatory function.Scientific reports · 2024Article
- Profiling migraine patients according to clinical and psychophysical characteristics: clinical validity of distinct migraine clusters.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study.Biomedicines · 2024Article
- [Habituation deficit study in patients with episodic migraine thru nociceptive blink reflex].Revista de neurologia · 2023Observational
- Cervical Impairments in Subjects with Chronic Migraine: An Observational Study.Life (Basel, Switzerland) · 2023Article
- Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study.Pain research & management · 2021Article
- Article
- Cortical pain processing in migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Effectiveness of manual therapy as a prophylactic treatment for migraine: a randomized controlled trial.Archives of physiotherapyArticle
- Cerebral peak alpha frequency: Associations with chronic pain onset and pain modulation.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo assess conditioned pain modulation efficiency in persons with and without migraine headaches.
designCross-sectional assessment of experimental pain.
settingUniversity campus and surrounding community in a large Midwestern US city. SUBJECTS: Twenty-three adults with and 32 without a history of migraine headaches participated in the study. Participants were mostly female (N = 40) with an average age of 23 years.
methodsFour electrocutaneous stimulations of the supraorbital branch of the left trigeminal nerve were delivered at 150% of an individually determined pain threshold. Conditioned pain modulation was assessed by applying a noxious counterstimulus (forearm ischemia) and delivering four more electrocutaneous stimulations. After each stimulation, pain and the nociceptive blink reflex were assessed. Depression and pain catastrophizing were assessed to control for the potential influence of these variables on pain modulation.
resultsParticipants with and without migraine headaches had similar baseline pain responsivity, without significant differences in pain report or nociceptive blink reflexes. Pain report was inhibited by conditioned pain modulation in both the migraine and control groups. However, unlike nonmigraine controls, participants with migraines did not exhibit an inhibition of nociceptive blink reflexes during the ischemia task. This pattern persisted after controlling for level of pain catastrophizing and depression.
conclusionsMigraine sufferers exhibited impaired conditioned pain modulation of the nociceptive blink reflex, suggesting a deficiency in inhibition of trigeminal nociception, which may contribute to the development of migraine headaches.
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