ArticleNeurosurgery2019
Amygdala and Hypothalamus: Historical Overview With Focus on Aggression.
Article in Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Hemispheric Asymmetries in Bipolar Disorder: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Deep brain stimulation of the hypothalamic region: a systematic review.Acta neurochirurgica · 2025Pooled it
- The amygdala as a therapeutic target for aggressive and disruptive behaviors: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- The Amygdala and Politics.Brain sciences · 2026Review
- Subregional hypothalamic volumes associate with childhood conduct problems in healthy adults.Brain imaging and behavior · 2026Article
- Hypothalamic subunit volumes and relations to violence and psychopathy in male offenders with or without a psychotic disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia.International journal of molecular sciences · 2026Review
- Lesion network mapping of focal injury-related aggression finds two distinct network injury patterns.Brain communications · 2026Article
- Mapping Lesion-Related Human Aggression to a Common Brain Network.Biological psychiatry · 2025Article
- Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour.International journal of molecular sciences · 2025Review
- Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults.Journal of psychiatric research · 2025Article
- Coordination and persistence of aggressive visual communication in Siamese fighting fish.Cell reports · 2025Article
- Electroconvulsive therapy (ECT) versus gamma knife radiosurgery for the treatment of severe aggression: Letter-to-the-Editor in response to RomeroSurgical neurology international · 2025Article
- Hypothalamic connectivities and self-evaluated aggression in young adults.bioRxiv : the preprint server for biology · 2024Article
- Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula.European archives of psychiatry and clinical neuroscience · 2024Article
- Amygdalar involvement in respiratory dysfunction.Frontiers in physiology · 2024Review
- Bilateral hypothalamotomy plus dominant amygdalotomy with Gamma Knife radiosurgery. A non-invasive alternative when everything has failed in the management of aggressive behavior disorder.Surgical neurology international · 2024Article
- Central amygdala is related to the reduction of aggressive behavior by monosodium glutamate ingestion during the period of development in an ADHD model rat.Frontiers in nutrition · 2024Article
- Hypothalamic volume in pedophilia with or without child sexual offense.European archives of psychiatry and clinical neuroscience · 2023Article
- PTSD and crime propensity: Stress systems, brain structures, and the nature of the relationship.Heliyon · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggressiveness has a high prevalence in psychiatric patients and is a major health problem. Two brain areas involved in the neural network of aggressive behavior are the amygdala and the hypothalamus. While pharmacological treatments are effective in most patients, some do not properly respond to conventional therapies and are considered medically refractory. In this population, surgical procedures (ie, stereotactic lesions and deep brain stimulation) have been performed in an attempt to improve symptomatology and quality of life. Clinical results obtained after surgery are difficult to interpret, and the mechanisms responsible for postoperative reductions in aggressive behavior are unknown. We review the rationale and neurobiological characteristics that may help to explain why functional neurosurgery has been proposed to control aggressive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.