ArticleInternational journal for parasitology. Drugs and drug resistance2019
Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro.
Article in International journal for parasitology. Drugs and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Halogenation of neolignan scaffolds reveals stage-specific anthelmintic activity against Haemonchus contortus.International journal for parasitology. Drugs and drug resistance · 2026Article
- High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes.International journal for parasitology. Drugs and drug resistance · 2026Article
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- Ovicidal effect of eucalyptus wood vinegar on gastrointestinal nematodes' eggs from sheep.Veterinary world · 2025Article
- Prediction and Prioritisation of Novel Anthelmintic Candidates from Public Databases Using Deep Learning and Available Bioactivity Data Sets.International journal of molecular sciences · 2025Article
- Evaluation of Serum Supplementation on the Development ofInternational journal of molecular sciences · 2025Article
- The Proteome and Lipidome of Extracellular Vesicles fromInternational journal of molecular sciences · 2023Article
- Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy onPharmaceutics · 2022Article
- In vitro nematocidal activity ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity againstMolecules (Basel, Switzerland) · 2021Article
- Natural Compounds from the Marine Brown AlgaPathogens (Basel, Switzerland) · 2020Article
- Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus.Parasites & vectors · 2019Article
- Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro.International journal for parasitology. Drugs and drug resistance · 2019Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295, and 14 related tetrahydroquinoxaline analogues against Haemonchus contortus was explored. These compounds were screened against parasitic larvae - exsheathed third-stage (xL3) and fourth-stage (L4) - using a whole-organism screening assay. All compounds were shown to have inhibitory effects on larval motility, development and growth, and induced evisceration through the excretory pore in xL3s. The estimated IC
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