ArticlePsychoneuroendocrinology2019
Daily interpersonal stress, sleep duration, and gene regulation during late adolescence.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes.Neurobiology of stress · 2026Article
- Development and validation of a risk prediction model for poor sleep quality among senior high school students in China.Scientific reports · 2025Article
- Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood.Brain, behavior, & immunity - health · 2025Article
- Profiles and Transitions of Sleep Disturbance and Depression Among Chinese Adolescents: The Predictive Roles of Life Stress and Resilience.Depression and anxiety · 2025Article
- Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics.Biomedicines · 2024Article
- Comprehensive Review of Chronic Stress Pathways and the Efficacy of Behavioral Stress Reduction Programs (BSRPs) in Managing Diseases.International journal of environmental research and public health · 2024Review
- Stress and Sleep Duration in Immune and Neuroendocrine Patterning. An Analytical Triangulation in ELSA.medRxiv : the preprint server for health sciences · 2024Article
- Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study.Brain, behavior, and immunity · 2024Article
- Fostering emotional well-being in adolescents: the role of physical activity, emotional intelligence, and interpersonal forgiveness.Frontiers in psychology · 2024Article
- Are sleep time and quality associated with inflammation in children and adolescents? A systematic review.Preventive medicine reports · 2023Review
- Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.Health psychology review · 2023Article
- Sleep duration moderates the associations between immune markers and corticolimbic function during stress in adolescents.Neuropsychologia · 2022Article
- Daily Stressors, Emotion Dynamics, and Inflammation in the MIDUS Cohort.International journal of behavioral medicine · 2022Article
- Does the moderator matter? Identification of multiple moderators of the association between peripheral inflammatory markers and depression severity in a large racially diverse community cohort.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Psychoneuroimmunology in the time of COVID-19: Why neuro-immune interactions matter for mental and physical health.Behaviour research and therapy · 2022Review
- Sleep duration and depression among adolescents: Mediation effect of collective integration.Frontiers in psychology · 2022Article
- Can You Sleep? - Effect of Retrospective Recall of Child Maltreatment on Sleep Parameters and the Mediating Role of Psychological Distress Among Students of Two German Universities.Nature and science of sleep · 2022Article
- Association between sleep habits and symptoms of oral disease in adolescents: the 2017 Korea Youth Risk Behavior Web-based Survey.BMC oral health · 2021Article
- Sleep and Inflammation During Adolescents' Transition to Young Adulthood.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2020Article
- Does Interpersonal Interaction Really Improve Emotion, Sleep Quality, and Self-Efficacy among Junior College Students?International journal of environmental research and public health · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundPsychological stress and poor sleep are associated with a wide range of negative health outcomes, which are thought to be mediated in part by alterations in immune processes. However, the molecular bases of links among stress, sleep, and immune processes are not completely understood, particularly during adolescence when sensitivity to stress and problems with sleep tend to increase. In the current study, we investigated whether various stressors (daily stress, major life events, perceived stress), sleep indices (duration, efficiency), and their interactions (e.g., moderating effects) are associated with expression of genes bearing response elements for transcription factors that regulate inflammatory and anti-viral processes.
methodEighty-seven late adolescents completed daily checklists of their social experiences across a 15-day period and reported on their major life events during the previous year. They also completed actigraphy-based assessments of sleep quality and duration during 8 consecutive nights. An average of 5.5 months later, participants reported on their global perceptions of stress during the previous month and provided blood samples for genome-wide expression profiling of mRNA from peripheral blood mononuclear cells (PBMCs).
resultsHigher levels of daily interpersonal stress and shorter sleep duration were associated with upregulation of inflammation-related genes bearing response elements for proinflammatory transcription factor nuclear factor kappa B (NF-κB). Shorter sleep duration was also linked to downregulation of antiviral-related genes bearing response elements for interferon response factors (IRFs). Lastly, there was a significant interaction between daily stress and shorter sleep duration, such that the association between daily stress and inflammation-related gene expression was exacerbated in the context of shorter sleep duration. Results were independent of sex, ethnicity, parent education, body mass index, and smoking and alcohol history.
conclusionEveryday interpersonal stress and shortened sleep can be consequential for upstream NF-κB signaling pathways relevant to inflammatory processes during late adolescence. Notably, the occurrence of both may lead to even greater activation of NF-κB signaling.
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